Influence of co-culture and soluble factors on epithelialization of a collagen matrix

Allison Hubel, Elizabeth Orwin

Research output: Contribution to journalConference articlepeer-review

Abstract

Interest in corneal wound healing has been fueled largely by the growth in surgical procedures including penetrating keratoplasty and refractive surgery. Recently, we have developed a collagen matrix designed to provide an important in vitro model for corneal wound healing. The matrix for this investigation was a porous collagen matrix composed of type I collagen from bovine corium supplemented with various proteoglycans. Results indicate that soluble factors produced by endothelial cells and insoluble factors produced by stromal fibroblasts influence epithelial layer formation on a collagen sponge.

Original languageEnglish (US)
JournalAnnals of Biomedical Engineering
Volume28
Issue numberSUPPL. 1
StatePublished - Dec 1 2000
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: Oct 12 2000Oct 14 2000

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