Influence of carbon nanomaterial defects on the formation of protein corona

Bishwambhar Sengupta, Wren E. Gregory, Jingyi Zhu, Siva Dasetty, Mehmet Karakaya, Jared M. Brown, Apparao M. Rao, John K. Barrows, Sapna Sarupria, Ramakrishna Podila

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


In any physiological media, carbon nanomaterials (CNM) strongly interact with biomolecules leading to the formation of biocorona, which subsequently dictate the physiological response and the fate of CNMs. Defects in CNMs play an important role not only in material properties but also in the determination of how materials interact at the nano-bio interface. In this article, we probed the influence of defect-induced hydrophilicity on the biocorona formation using micro-Raman, photoluminescence, infrared spectroscopy, electrochemistry, and molecular dynamics simulations. Our results show that the interaction of proteins (albumin and fibrinogen) with CNMs is strongly influenced by charge-transfer between them, inducing protein unfolding which enhances conformational entropy and higher protein adsorption.

Original languageEnglish (US)
Pages (from-to)82395-82402
Number of pages8
JournalRSC Advances
Issue number100
StatePublished - Sep 23 2015
Externally publishedYes

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Publisher Copyright:
© 2015 The Royal Society of Chemistry.


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