Influence of blood transfusions on immune responsiveness

R. H. Kerman, C. T. van Buren, W. Payne, S. Flechner, G. Agostino, S. Conley, E. Brewer, B. D. Kahan

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35 Scopus citations

Abstract

Patients receiving >5 BT are more likely to display weak immune responsiveness, normal percentages of OKT 8 + T cells, and strong suppressor cell function in vitro. These immunologic traits may account for the beneficial effect of transfusions on graft survival. Phenotypic enumeration of OKT 8+ cells does not indicate suppressor function of these cells, since end-stage renal disease patients with normal OKT 8+ cells with >5 BT had greater suppressor function than those with <5 BT. These studies suggest that long-term evaluations of immune responsiveness may more accurately reflect influence of transfusions than isolated early posttransfusion testing.

Original languageEnglish (US)
Pages (from-to)335-337
Number of pages3
JournalTransplantation Proceedings
Volume14
Issue number2
StatePublished - Dec 1 1982

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    Kerman, R. H., van Buren, C. T., Payne, W., Flechner, S., Agostino, G., Conley, S., Brewer, E., & Kahan, B. D. (1982). Influence of blood transfusions on immune responsiveness. Transplantation Proceedings, 14(2), 335-337.