Influence of blood transfusions on immune responsiveness

R. H. Kerman, C. T. van Buren, W. Payne, S. Flechner, G. Agostino, S. Conley, E. Brewer, B. D. Kahan

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Patients receiving >5 BT are more likely to display weak immune responsiveness, normal percentages of OKT 8 + T cells, and strong suppressor cell function in vitro. These immunologic traits may account for the beneficial effect of transfusions on graft survival. Phenotypic enumeration of OKT 8+ cells does not indicate suppressor function of these cells, since end-stage renal disease patients with normal OKT 8+ cells with >5 BT had greater suppressor function than those with <5 BT. These studies suggest that long-term evaluations of immune responsiveness may more accurately reflect influence of transfusions than isolated early posttransfusion testing.

Original languageEnglish (US)
Pages (from-to)335-337
Number of pages3
JournalTransplantation proceedings
Issue number2
StatePublished - 1982


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