Influence of asparaginase on a combination chemotherapy protocol for canine multicentric lymphoma

Antonella Borgatti Jeffreys, Deborah W. Knapp, William W. Carlton, Rosanne M. Thomas, Patty L. Bonney, A. deGortari, Michael D. Lucroy

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Combination chemotherapy is superior to single-agent chemotherapy for treating canine lymphoma, but the effect of each drug on efficacy remains unknown. By comparing 34 dogs treated with a modified cyclophosphamide, vincristine, prednisone (COP) chemotherapy protocol and 42 dogs given asparaginase in the induction phase of the same protocol, the effect of asparaginase on the chemotherapeutic protocol was determined. Both groups were compared based on clinical response at 2 weeks and 6 weeks, and on the progression-free interval. Asparaginase did not significantly increase the likelihood of a clinical remission or prolong the initial progression-free interval in the dogs studied.

Original languageEnglish (US)
Pages (from-to)221-226
Number of pages6
JournalJournal of the American Animal Hospital Association
Volume41
Issue number4
DOIs
StatePublished - 2005

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