Inflammatory Macrophage Interleukin-1β Mediates High-Fat Diet-Induced Heart Failure With Preserved Ejection Fraction

Hong Liu; Yimao Huang; Yang Zhao; Gyeoung Jin Kang; Feng Feng; Xiaodan Wang; Man Liu; Guangbin Shi; Xavier Revelo; David Bernlohr; Samuel C. Dudley

doi:10.1016/j.jacbts.2022.08.003

Inflammatory Macrophage Interleukin-1β Mediates High-Fat Diet-Induced Heart Failure With Preserved Ejection Fraction

Hong Liu, Yimao Huang, Yang Zhao, Gyeoung Jin Kang, Feng Feng, Xiaodan Wang, Man Liu, Guangbin Shi, Xavier Revelo, David Bernlohr, Samuel C. Dudley

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Diabetes mellitus (DM) is a main risk factor for diastolic dysfunction (DD) and heart failure with preserved ejection fraction. High-fat diet (HFD) mice presented with diabetes mellitus, DD, higher cardiac interleukin (IL)-1β levels, and proinflammatory cardiac macrophage accumulation. DD was significantly ameliorated by suppressing IL-1β signaling or depleting macrophages. Mice with macrophages unable to adopt a proinflammatory phenotype were low in cardiac IL-1β levels and were resistant to HFD-induced DD. IL-1β enhanced mitochondrial reactive oxygen species (mitoROS) in cardiomyocytes, and scavenging mitoROS improved HFD-induced DD. In conclusion, macrophage-mediated inflammation contributed to HFD-associated DD through IL-1β and mitoROS production.

Original language	English (US)
Pages (from-to)	174-185
Number of pages	12
Journal	JACC: Basic to Translational Science
Volume	8
Issue number	2
DOIs	https://doi.org/10.1016/j.jacbts.2022.08.003
State	Published - Feb 2023

Bibliographical note

Funding Information:
The authors thank D. Dicky for the assistance on FABP4 mice breeding and maintenance.

Publisher Copyright:
© 2023 The Authors

Keywords

HFpEF
IL-1β
diabetes
diastolic dysfunction
inflammation
macrophage
mitochondria

PubMed: MeSH publication types

Journal Article

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jacbts.2022.08.003

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@article{b89bc39165364225ac5db3593312c7ec,

title = "Inflammatory Macrophage Interleukin-1β Mediates High-Fat Diet-Induced Heart Failure With Preserved Ejection Fraction",

abstract = "Diabetes mellitus (DM) is a main risk factor for diastolic dysfunction (DD) and heart failure with preserved ejection fraction. High-fat diet (HFD) mice presented with diabetes mellitus, DD, higher cardiac interleukin (IL)-1β levels, and proinflammatory cardiac macrophage accumulation. DD was significantly ameliorated by suppressing IL-1β signaling or depleting macrophages. Mice with macrophages unable to adopt a proinflammatory phenotype were low in cardiac IL-1β levels and were resistant to HFD-induced DD. IL-1β enhanced mitochondrial reactive oxygen species (mitoROS) in cardiomyocytes, and scavenging mitoROS improved HFD-induced DD. In conclusion, macrophage-mediated inflammation contributed to HFD-associated DD through IL-1β and mitoROS production.",

keywords = "HFpEF, IL-1β, diabetes, diastolic dysfunction, inflammation, macrophage, mitochondria",

author = "Hong Liu and Yimao Huang and Yang Zhao and Kang, {Gyeoung Jin} and Feng Feng and Xiaodan Wang and Man Liu and Guangbin Shi and Xavier Revelo and David Bernlohr and Dudley, {Samuel C.}",

note = "Funding Information: The authors thank D. Dicky for the assistance on FABP4 mice breeding and maintenance. Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = feb,

doi = "10.1016/j.jacbts.2022.08.003",

language = "English (US)",

volume = "8",

pages = "174--185",

journal = "JACC: Basic to Translational Science",

issn = "2452-302X",

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TY - JOUR

T1 - Inflammatory Macrophage Interleukin-1β Mediates High-Fat Diet-Induced Heart Failure With Preserved Ejection Fraction

AU - Liu, Hong

AU - Huang, Yimao

AU - Zhao, Yang

AU - Kang, Gyeoung Jin

AU - Feng, Feng

AU - Wang, Xiaodan

AU - Liu, Man

AU - Shi, Guangbin

AU - Revelo, Xavier

AU - Bernlohr, David

AU - Dudley, Samuel C.

PY - 2023/2

Y1 - 2023/2

N2 - Diabetes mellitus (DM) is a main risk factor for diastolic dysfunction (DD) and heart failure with preserved ejection fraction. High-fat diet (HFD) mice presented with diabetes mellitus, DD, higher cardiac interleukin (IL)-1β levels, and proinflammatory cardiac macrophage accumulation. DD was significantly ameliorated by suppressing IL-1β signaling or depleting macrophages. Mice with macrophages unable to adopt a proinflammatory phenotype were low in cardiac IL-1β levels and were resistant to HFD-induced DD. IL-1β enhanced mitochondrial reactive oxygen species (mitoROS) in cardiomyocytes, and scavenging mitoROS improved HFD-induced DD. In conclusion, macrophage-mediated inflammation contributed to HFD-associated DD through IL-1β and mitoROS production.

AB - Diabetes mellitus (DM) is a main risk factor for diastolic dysfunction (DD) and heart failure with preserved ejection fraction. High-fat diet (HFD) mice presented with diabetes mellitus, DD, higher cardiac interleukin (IL)-1β levels, and proinflammatory cardiac macrophage accumulation. DD was significantly ameliorated by suppressing IL-1β signaling or depleting macrophages. Mice with macrophages unable to adopt a proinflammatory phenotype were low in cardiac IL-1β levels and were resistant to HFD-induced DD. IL-1β enhanced mitochondrial reactive oxygen species (mitoROS) in cardiomyocytes, and scavenging mitoROS improved HFD-induced DD. In conclusion, macrophage-mediated inflammation contributed to HFD-associated DD through IL-1β and mitoROS production.

KW - HFpEF

KW - IL-1β

KW - diabetes

KW - diastolic dysfunction

KW - inflammation

KW - macrophage

KW - mitochondria

UR - http://www.scopus.com/inward/record.url?scp=85146704351&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85146704351&partnerID=8YFLogxK

U2 - 10.1016/j.jacbts.2022.08.003

DO - 10.1016/j.jacbts.2022.08.003

M3 - Article

C2 - 36908663

AN - SCOPUS:85146704351

SN - 2452-302X

VL - 8

SP - 174

EP - 185

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

IS - 2

ER -

Inflammatory Macrophage Interleukin-1β Mediates High-Fat Diet-Induced Heart Failure With Preserved Ejection Fraction

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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