Inflammatory cytokines as a third signal for T cell activation

Julie M. Curtsinger, Matthew F. Mescher

Research output: Contribution to journalReview articlepeer-review

379 Scopus citations


CD8 T cells require a third signal, along with Ag and costimulation, to make a productive response and avoid death and/or tolerance induction. Recent studies indicate that IL-12 and Type I IFN (IFNα/β) are the major sources of signal 3 in a variety of responses, and that the two cytokines stimulate a common regulatory program involving altered expression of about 350 genes. Signal 3-driven chromatin remodeling is likely to play a major role in this regulation. Although less well studied, there is emerging evidence that CD4 T cells may also require a 'third signal' for a productive response and that IL-1 can provide this signal. Signal 3 cytokines can replace adjuvants in supporting in vivo T cell responses to peptide and protein antigens, and a better understanding of their activities and mechanisms should contribute to more rational design of vaccines.

Original languageEnglish (US)
Pages (from-to)333-340
Number of pages8
JournalCurrent Opinion in Immunology
Issue number3
StatePublished - Jun 2010

Bibliographical note

Funding Information:
The work summarized here from our laboratory was supported by National Institutes of Health Grants RO1 AI34824 and PO1AI35296 .


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