Inflammatory and Physiological Consequences of Debridement of Fibrous Tissue after Volumetric Muscle Loss Injury

Benjamin T. Corona, Jessica C. Rivera, Sarah M. Greising

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Volumetric muscle loss (VML) injuries present chronic loss of muscle fibers followed by expansive fibrotic tissue deposition. Regenerative medicine therapies are under development to promote regeneration. However, mitigation of the expansive fibrous tissue is required for integration with the remaining muscle. Using a porcine VML model, delayed debridement of injury fibrosis was performed 3 months post-VML and observed for an additional 4 weeks. A second group underwent the initial VML and was observed for 4 weeks, allowing comparison of initial fibrosis formation and debrided groups. The following salient observations were made: (i) debridement neither exacerbated nor ameliorated strength deficits; (ii) debridement results in recurrent fibrotic tissue deposition of a similar magnitude and composition as acute VML injury; and (iii) similarly upregulated transcriptional fibrotic and transcriptional pathways persist 4 weeks after initial VML or delayed debridement. This highlights the need for future studies to investigate adjunctive antifibrotic treatments for the fibrosed musculature.

Original languageEnglish (US)
Pages (from-to)208-217
Number of pages10
JournalClinical and Translational Science
Volume11
Issue number2
DOIs
StateAccepted/In press - Jan 1 2017

Bibliographical note

Funding Information:
Source of Funding. Studies were funded through the Congressionally Directed Medical Research Program (Award #MR140099 awarded to B.T.C.).

PubMed: MeSH publication types

  • Journal Article

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