Highly purified concanavalin A and other lectins injected in small amounts into the footpads of mice and rats induce an an intense and reproducible edema. Con A is eliminated from the site of injection at a slow rate, which may explain the prolonged nature of the inflammatory response it induces. Some advantages of the use of concanavalin A for the induction of experimental inflammation are discussed.
|Original language||English (US)|
|Number of pages||4|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Jun 1974|
Bibliographical noteFunding Information:
This investigation was supported by grant AI-10265 from The National Institutes of Health and by Contract NIH-NCI-72-3207 within the Special Virus-Cancer Program of NIH, US Public Health Service.