Inflammation Induced by Concanavalin A and Other Lectins

W. Thomas Shier, Joseph T. Trotter, Christopher L. Reading

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Highly purified concanavalin A and other lectins injected in small amounts into the footpads of mice and rats induce an an intense and reproducible edema. Con A is eliminated from the site of injection at a slow rate, which may explain the prolonged nature of the inflammatory response it induces. Some advantages of the use of concanavalin A for the induction of experimental inflammation are discussed.

Original languageEnglish (US)
Pages (from-to)590-593
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number2
StatePublished - Jun 1974

Bibliographical note

Funding Information:
This investigation was supported by grant AI-10265 from The National Institutes of Health and by Contract NIH-NCI-72-3207 within the Special Virus-Cancer Program of NIH, US Public Health Service.


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