We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy-naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease.
Bibliographical noteFunding Information:
Financial support. This work was supported by the National Institute of Allergy and Infectious Diseases (grant numbers UM1-AI068641, UM1-AI120197; United States); Agence Nationale de Recherches sur le SIDA et les Hipatites Virales (France); National Health and Medical Research Council (Australia); National Research Foundation (Denmark); Bundes Ministerium f|r Bildung und Forschung (Germany); European AIDS Treatment Network, Medical Research Council (United Kingdom); National Institute for Health Research, National Health Service (United Kingdom); and the University of Minnesota.
© The Author(s) 2018.
- Arterial elasticity
- Cardiovascular disease
- HIV infection
- Systemic inflammation
- Vascular dysfunction