Inflammation associates with impaired small arterial elasticity early in HIV disease

INSIGHT START (Strategic Timing of AntiRetroviral Treatment) Study Group

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy-naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease.

Original languageEnglish (US)
JournalOpen Forum Infectious Diseases
Volume5
Issue number6
DOIs
StatePublished - Jun 1 2018

Bibliographical note

Funding Information:
Financial support. This work was supported by the National Institute of Allergy and Infectious Diseases (grant numbers UM1-AI068641, UM1-AI120197; United States); Agence Nationale de Recherches sur le SIDA et les Hipatites Virales (France); National Health and Medical Research Council (Australia); National Research Foundation (Denmark); Bundes Ministerium f|r Bildung und Forschung (Germany); European AIDS Treatment Network, Medical Research Council (United Kingdom); National Institute for Health Research, National Health Service (United Kingdom); and the University of Minnesota.

Publisher Copyright:
© The Author(s) 2018.

Keywords

  • Arterial elasticity
  • Cardiovascular disease
  • HIV infection
  • Systemic inflammation
  • Vascular dysfunction

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