Infiltrados inflamatorios en lesiones melanocíticas

Translated title of the contribution: Inflammatory infiltrates in melanocytic lesions

Alisha Relan, Sabina Desar, Brian Dunnette, Ryan Shanley, Alessio Giubellino

Research output: Contribution to journalArticlepeer-review

Abstract

SUMMARY: Inflammatory infiltrates are frequently present in melanocytic lesions, with different distribution and composition. Much attention has been devoted to tumor-infiltrating lymphocytes (TIL) in the tumor microenvironment, establishing their prognostic and predictive value in many malignancies, including melanoma. However, lymphocytes, albeit the most numerous and consistent presence, constitute only part of the immune microenvironment. Other inflammatory cells, including neutrophils, plasma cells, eosinophils and mast cells, are found in melanoma and other melanocytic lesions.Few studies offer a detailed count of these inflammatory infiltrates across the spectrum of melanocytic lesions. By using whole slide image analysis and open source software, in the present study we report the enumeration of different inflammatory infiltrates in benign melanocytic nevi, dysplastic nevi, melanoma in situ and invasive malignant melanomas. Significant higher numbers of plasma cells and neutrophils were observed in melanoma. These results indicate that composition of the inflammatory infiltrate may contribute to the diagnostic algorithm of melanocytic lesions.

Translated title of the contributionInflammatory infiltrates in melanocytic lesions
Original languageSpanish
Pages (from-to)512-519
Number of pages8
JournalInternational Journal of Morphology
Volume39
Issue number2
DOIs
StatePublished - 2021

Bibliographical note

Funding Information:
This work was supported by start-up funds from the Department of Laboratory Medicine and Pathology/Masonic Cancer Center, University of Minnesota. Research reported in this publication was also supported by NIH grant P30 CA77598 utilizing the Biostatistics and Bioinformatics Core shared resource of the Masonic Cancer Center, University of Minnesota and by the National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1TR002494. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© 2021, Universidad de la Frontera. All rights reserved.

Keywords

  • Inflammatory cells
  • Lymphocytes
  • Melanoma
  • Neutrophils
  • Nevi
  • Plasma cells

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