Inferior frontal white matter anisotropy and negative symptoms of schizophrenia: A diffusion tensor imaging study

Adam Wolkin, Steven J. Choi, Sandor Szilagyi, Michael Sanfilipo, John P. Rotrosen, Kelvin O. Lim

Research output: Contribution to journalArticlepeer-review

135 Scopus citations

Abstract

Objective: The purpose of this study was test the hypothesis that abnormalities of inferior frontal white matter are related to the negative symptoms of schizophrenia. Method: Fractional anisotropy of white matter tracts in the prefrontal area of 10 schizophrenic patients was determined by diffusion tensor imaging. Patients were also assessed for severity of negative symptoms by using the Schedule for the Assessment of Negative Symptoms (SANS). Results: Inferior frontal white matter fractional anisotropy was significantly inversely correlated with the SANS global ratings of negative symptoms. Conclusions: These data, while preliminary, suggest that impaired white matter integrity in the inferior frontal region may be associated with the severity of negative symptoms in schizophrenia.

Original languageEnglish (US)
Pages (from-to)572-574
Number of pages3
JournalAmerican Journal of Psychiatry
Volume160
Issue number3
DOIs
StatePublished - Mar 2003

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