Infectious prions in the saliva and blood of deer with chronic wasting disease

Candace K. Mathiason, Jenny G. Powers, Sallie J. Dahmes, David A. Osborn, Karl V. Miller, Robert J. Warren, Gary L. Mason, Sheila A. Hays, Jeanette Hayes-Klug, Davis M. Seelig, Margaret A. Wild, Lisa L. Wolfe, Terry R. Spraker, Michael W. Miller, Christina J. Sigurdson, Glenn C. Telling, Edward A. Hoover

Research output: Contribution to journalArticle

325 Citations (Scopus)

Abstract

A critical concern in the transmission of prion diseases, including chronic wasting disease (CWD) of cervids, is the potential presence of prions in body fluids. To address this issue directly, we exposed cohorts of CWD-naïve deer to saliva, blood, or urine and feces from CWD-positive deer. We found infectious prions capable of transmitting CWD in saliva (by the oral route) and in blood (by transfusion). The results help to explain the facile transmission of CWD among cervids and prompt caution concerning contact with body fluids in prion infections.

Original languageEnglish (US)
Pages (from-to)133-136
Number of pages4
JournalScience
Volume314
Issue number5796
DOIs
StatePublished - Oct 6 2006

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Chronic Wasting Disease
Deer
Prions
Saliva
Body Fluids
Prion Diseases
Feces
Blood Transfusion
Urine
Infection

Cite this

Mathiason, C. K., Powers, J. G., Dahmes, S. J., Osborn, D. A., Miller, K. V., Warren, R. J., ... Hoover, E. A. (2006). Infectious prions in the saliva and blood of deer with chronic wasting disease. Science, 314(5796), 133-136. https://doi.org/10.1126/science.1132661

Infectious prions in the saliva and blood of deer with chronic wasting disease. / Mathiason, Candace K.; Powers, Jenny G.; Dahmes, Sallie J.; Osborn, David A.; Miller, Karl V.; Warren, Robert J.; Mason, Gary L.; Hays, Sheila A.; Hayes-Klug, Jeanette; Seelig, Davis M.; Wild, Margaret A.; Wolfe, Lisa L.; Spraker, Terry R.; Miller, Michael W.; Sigurdson, Christina J.; Telling, Glenn C.; Hoover, Edward A.

In: Science, Vol. 314, No. 5796, 06.10.2006, p. 133-136.

Research output: Contribution to journalArticle

Mathiason, CK, Powers, JG, Dahmes, SJ, Osborn, DA, Miller, KV, Warren, RJ, Mason, GL, Hays, SA, Hayes-Klug, J, Seelig, DM, Wild, MA, Wolfe, LL, Spraker, TR, Miller, MW, Sigurdson, CJ, Telling, GC & Hoover, EA 2006, 'Infectious prions in the saliva and blood of deer with chronic wasting disease', Science, vol. 314, no. 5796, pp. 133-136. https://doi.org/10.1126/science.1132661
Mathiason CK, Powers JG, Dahmes SJ, Osborn DA, Miller KV, Warren RJ et al. Infectious prions in the saliva and blood of deer with chronic wasting disease. Science. 2006 Oct 6;314(5796):133-136. https://doi.org/10.1126/science.1132661
Mathiason, Candace K. ; Powers, Jenny G. ; Dahmes, Sallie J. ; Osborn, David A. ; Miller, Karl V. ; Warren, Robert J. ; Mason, Gary L. ; Hays, Sheila A. ; Hayes-Klug, Jeanette ; Seelig, Davis M. ; Wild, Margaret A. ; Wolfe, Lisa L. ; Spraker, Terry R. ; Miller, Michael W. ; Sigurdson, Christina J. ; Telling, Glenn C. ; Hoover, Edward A. / Infectious prions in the saliva and blood of deer with chronic wasting disease. In: Science. 2006 ; Vol. 314, No. 5796. pp. 133-136.
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