Infection of gnotobiotic pigs with an Escherichia coli O157:H7 strain associated with an outbreak of hemorrhagic colitis

D. H. Francis, J. E. Collins, J. R. Duimstra

Research output: Contribution to journalArticlepeer-review

91 Scopus citations

Abstract

Gnotobiotic pigs inoculated with an Escherichia coli O157:H7 strain isolated from a human with hemorrhagic colitis developed anorexia, lethargy, and watery diarrhea. Bacteria diffusely colonized the cecum and colon surfaces and the crypt epithelium. At bacterial attachment sites, microvilli were effaced, and epithelial cells were irregularly shaped, rounded, or detached. Submucosa, lamina propria, and mesentery were markedly edematous and contained many inflammatory cells.

Original languageEnglish (US)
Pages (from-to)953-956
Number of pages4
JournalInfection and immunity
Volume51
Issue number3
DOIs
StatePublished - 1986

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