Infection and transmission dynamics of Turkey arthritis reovirus in different age Turkeys

Rahul Kumar, Tamer A Sharafeldin, Sagar M Goyal, Sunil K. Mor, Robert E Porter

Research output: Contribution to journalArticlepeer-review

Abstract

Turkey arthritis reovirus (TARV) has been established as a cause of lameness in meat type turkeys in the past decade. However, no information is available on the age susceptibility of TARV or its transmission dynamics. We conducted this study to determine the age at which turkey poults are susceptible to TARV infection and whether infected birds can horizontally transmit the virus to their non-infected pen mates (sentinels). Five groups of turkeys were orally inoculated with TARV (∼106 TCID50/ml) at 2, 7, 14, 21 and 28 days of age (DOA). Two days after each challenge, four uninfected sentinel turkeys of equal age were added to the virus-inoculated groups. At one- and two-weeks post infection, turkeys from each group, including two sentinels, were euthanized followed by necropsy. Inoculated birds in all age groups had TARV replication in the intestine and gastrocnemius tendon with no statistically significant variation at p < 0.5. Furthermore, the inoculated birds at different age groups showed consistently high gastrocnemius tendon histologic lesion scores while birds in the 28-days-old age group had numerically lower lesion scores at 14 days post inoculation (dpi). The sentinels, in turn, also showed virus replication in their intestines and tendons and histologic lesions in gastrocnemius tendons. The findings indicate that turkeys at the age of 28 days or less are susceptible to infection with TARV following oral challenge. It was also found that TARV-infected birds could transmit the infection to naïve sentinel turkeys of the same age.

Original languageEnglish (US)
Article number105790
JournalMicrobial Pathogenesis
Volume173
DOIs
StatePublished - Dec 2022

Bibliographical note

Funding Information:
This study was supported in part by a grant from University of Minnesota Rapid Agricultural Response Fund (RARF) . R.K. acknowledges the financial assistance of the Indian Council of Agricultural Research (ICAR) through the ICAR International Fellowship for PhD.

Publisher Copyright:
© 2022 Elsevier Ltd

Keywords

  • Age susceptibility
  • Horizontal transmission
  • Reovirus
  • Sentinels
  • Turkey arthritis reovirus
  • Virus shedding

PubMed: MeSH publication types

  • Journal Article

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