Infection and atherosclerosis: Potential roles of pathogen burden and molecular mimicry

Stephen E. Epstein, Jianhui Zhu, Mary Susan Burnett, Yi Fu Zhou, Gregory Vercellotti, David Hajjar

Research output: Contribution to journalReview articlepeer-review

185 Scopus citations


Infection has been implicated as a cause of atherosclerosis since the first half of the 19th century. Over the years, sporadic publications have appeared in the literature reflecting a persistent but relatively low level of research activity in this area. In the last decade, however, publications relating to this topic have increased markedly. And very recently, new epidemiological and mechanistic data relating infection to several different diseases, including atherosclerosis, have appeared, stimulating the emergence of important paradigm shifts in how we think about the causes of chronic disease. The following article reviews some of these newer concepts as they relate to a possible role of infection in atherosclerosis.

Original languageEnglish (US)
Pages (from-to)1417-1420
Number of pages4
JournalArteriosclerosis, thrombosis, and vascular biology
Issue number6
StatePublished - 2000


  • Atherosclerosis
  • Infection
  • Mechanisms


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