Induction of tissue transglutaminase in mouse peritoneal macrophages

M. P. Murtaugh, K. Mehta, J. Johnson, M. Myers, R. L. Juliano, P. J. Davies

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


Tissue transglutaminase accumulates rapidly and to very high levels (1-2% of cellular protein) in mouse peritoneal macrophages cultured in mouse serum. The induction is due to accelerated synthesis of the enzyme (150-fold increase) that occurs within 90 min of exposure of the cells to a heat-labile constituent of serum or plasma. The induction is reversible and is not reproduced by known activators of macrophage function such as lipopolysaccharide, muramyl dipeptide, and tuftsin. In animals, elevated levels of tissue transglutaminase are also found in inflammatory macrophages elicited by thioglycolate broth.

Original languageEnglish (US)
Pages (from-to)11074-11081
Number of pages8
JournalJournal of Biological Chemistry
Issue number18
StatePublished - 1983


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