Abstract
By exploiting the permeability of PDMS fabricated on the microfluidic system, it is possible to deliver hormone-like small molecules into stored microdroplets encapsulating cells, which are harbouring a plasmid to detect quorum sensing molecules. The ability to change the condition of microdroplets provides a tool to investigate responses of individual cells under controllable chemical environments at a given initial condition. This study will be helpful to understand the heterogeneity of cells to different regulators during their lifecycle by simply switching the reservoir conditions in predetermined manners.
| Original language | English (US) |
|---|---|
| Title of host publication | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 |
| Pages | 656-658 |
| Number of pages | 3 |
| Volume | 1 |
| State | Published - Dec 1 2010 |
| Event | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands Duration: Oct 3 2010 → Oct 7 2010 |
Other
| Other | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 |
|---|---|
| Country/Territory | Netherlands |
| City | Groningen |
| Period | 10/3/10 → 10/7/10 |
Keywords
- Control of environment
- Microdroplet
- Permeability of PDMS
- Quorum sensing