Induction of mutagenesis and transformation by the extract of alernaria alternata isolated from grains in linxian, China

Zigang Dong; Guiting Liu; Ziming Dong; Yuzhen Qian; Yuhui An; Jian Miao; Yingzhong Zhen

doi:10.1093/carcin/8.7.989

Induction of mutagenesis and transformation by the extract of alernaria alternata isolated from grains in linxian, China

Zigang Dong, Guiting Liu, Ziming Dong, Yuzhen Qian, Yuhui An, Jian Miao, Yingzhong Zhen

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Abstract

Alternaria alternata is commonly found in the grain in areas of high incidence of oesophageal cancer and is a suspected cancer-causing factor in Linxian, China. In this study, this fungus was isolated from corn in Linxian and cultured. The extract of this fungus was shown to induce 6-thioguanine-resistant mutants in V79 cells and cause transformation of NIH/3T3 mouse fibroblast cells. Metabolic activation does not seem to be required for these activities. The mutagenic and transforming activities of the extract of A. alternata suggest that this fungus may be a factor in the etiology of oesophageal cancer in Linxian.

Original language	English (US)
Pages (from-to)	989-991
Number of pages	3
Journal	Carcinogenesis
Volume	8
Issue number	7
DOIs	https://doi.org/10.1093/carcin/8.7.989
State	Published - Jul 1987
Externally published	Yes

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abstract = "Alternaria alternata is commonly found in the grain in areas of high incidence of oesophageal cancer and is a suspected cancer-causing factor in Linxian, China. In this study, this fungus was isolated from corn in Linxian and cultured. The extract of this fungus was shown to induce 6-thioguanine-resistant mutants in V79 cells and cause transformation of NIH/3T3 mouse fibroblast cells. Metabolic activation does not seem to be required for these activities. The mutagenic and transforming activities of the extract of A. alternata suggest that this fungus may be a factor in the etiology of oesophageal cancer in Linxian.",

author = "Zigang Dong and Guiting Liu and Ziming Dong and Yuzhen Qian and Yuhui An and Jian Miao and Yingzhong Zhen",

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T1 - Induction of mutagenesis and transformation by the extract of alernaria alternata isolated from grains in linxian, China

AU - Dong, Zigang

AU - Liu, Guiting

AU - Dong, Ziming

AU - Qian, Yuzhen

AU - An, Yuhui

AU - Miao, Jian

AU - Zhen, Yingzhong

PY - 1987/7

Y1 - 1987/7

N2 - Alternaria alternata is commonly found in the grain in areas of high incidence of oesophageal cancer and is a suspected cancer-causing factor in Linxian, China. In this study, this fungus was isolated from corn in Linxian and cultured. The extract of this fungus was shown to induce 6-thioguanine-resistant mutants in V79 cells and cause transformation of NIH/3T3 mouse fibroblast cells. Metabolic activation does not seem to be required for these activities. The mutagenic and transforming activities of the extract of A. alternata suggest that this fungus may be a factor in the etiology of oesophageal cancer in Linxian.

AB - Alternaria alternata is commonly found in the grain in areas of high incidence of oesophageal cancer and is a suspected cancer-causing factor in Linxian, China. In this study, this fungus was isolated from corn in Linxian and cultured. The extract of this fungus was shown to induce 6-thioguanine-resistant mutants in V79 cells and cause transformation of NIH/3T3 mouse fibroblast cells. Metabolic activation does not seem to be required for these activities. The mutagenic and transforming activities of the extract of A. alternata suggest that this fungus may be a factor in the etiology of oesophageal cancer in Linxian.

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Induction of mutagenesis and transformation by the extract of alernaria alternata isolated from grains in linxian, China

Abstract

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