Induction of mucous cell metaplasia by tumor necrosis factor alpha in rat middle ear: The pathological basis for mucin hyperproduction in mucoid otitis media

Hirokazu Kawano, Atsushi Haruta, Yasuhiro Tsuboi, Youngki Kim, Patricia A. Schachern, Michael M. Paparella, Jizhen Lin

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Mucoid otitis media (MOM), one of the leading causes of acquired hearing loss in children, is characterized by mucous cell hyperplasia in the middle ear cleft associated with mucin accumulation in the middle ear cavity. The factors that stimulate mucous cell metaplasia-hyperplasia and mucin hyperproduction are poorly understood. Recent studies demonstrated that tumor necrosis factor α (TNF-α), present in human middle ear effusion, stimulated mucin production in vitro and up-regulated mucin gene expression in vivo. These findings suggest that TNF-α is important in the development of mucous cell metaplasia-hyperplasia. This study demonstrated that inoculation of TNF-α into the middle ear cavity followed by eustachian tube obstruction stimulated mucous cell metaplasia-hyperplasia in the middle ear cleft, accompanied by abundant mucin or mucin-like glycoproteins in the middle ear effusion - a phenotype of MOM in humans. This finding suggests that TNF-α plays a key role in the pathogenesis of MOM through induction of mucous cell metaplasia-hyperplasia and mucin production.

Original languageEnglish (US)
Pages (from-to)415-422
Number of pages8
JournalAnnals of Otology, Rhinology and Laryngology
Volume111
Issue number5 I
DOIs
StatePublished - 2002

Keywords

  • Mucin
  • Mucoid otitis media
  • Mucous cell metaplasia
  • Sprague-Dawley rat
  • Tumor necrosis factor α

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