Induction of interleukin (IL)-1β and IL-8 mRNA expression in porcine macrophages by lipopolysaccharide from Serpulina hyodysenteriae

Randy E. Sacco, Stuart K. Nibbelink, Mary J O Baarsch, Michael P Murtaugh, Michael J. Wannemuehler

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Lipopolysaccharide (LPS) is a classic inducer of inflammatory cytokines and is a key virulence factor for most gram-negative pathogens. The effect of phenol-water (LPS) and butanol-water (endotoxin) extracts from Serpulina hyodysenteriae on inflammatory cytokine mRNA expression from porcine alveolar macrophages was investigated. The LPS and endotoxin extracts from S. hyodysenteriae induced a dose-dependent expression of interleukin 1β (IL- 1β) and IL-8 which was weak compared with the responses induced by Escherichia coli LPS. In addition, the spirochetal extracts induced no detectable upregulation of mRNA expression for either IL-6 or tumor necrosis factor alpha.

Original languageEnglish (US)
Pages (from-to)4369-4372
Number of pages4
JournalInfection and immunity
Volume64
Issue number10
DOIs
StatePublished - 1996

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