Induction of heme oxygenase-1 inhibits cell death in crotonaldehyde-stimulated HepG2 cells via the PKC-δ -p38 -Nrf2 pathway

Keyphrases

• Protein Kinase 100%
• Heme oxygenase-1 (HO-1) 100%
• Cell Death 100%
• Crotonaldehyde 100%
• HepG2 Cells 100%
• Nrf2 Pathway 100%
• Small Interfering RNA (siRNA) 20%
• Hepatocellular Carcinoma Cells 20%
• Oxidative Stress 10%
• Risk Factors 10%
• In Cancer 10%
• Cell Proliferation 10%
• Signaling Pathway 10%
• Cell Survival 10%
• Cancer Cells 10%
• Adverse Effects 10%
• Cigarette Smoking 10%
• Cell Resistance 10%
• Lipid Peroxidation Products 10%
• Apoptosis Inhibition 10%
• Anti-apoptotic 10%
• G1 Phase 10%
• Nuclear Translocation 10%
• Tumor Resistance 10%
• Specific Inhibitor 10%
• P38 MAPK Pathway 10%
• P38 Mitogen-activated Protein Kinase (p38 MAPK) 10%
• End-labelling 10%
• Blockage 10%
• Environmental Pollutants 10%
• Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 10%
• Cellular Defense Mechanism 10%
• Zinc Protoporphyrin 10%
• Protein Kinase C Pathway 10%
• Resistance to Oxidative Stress 10%
• Inhibition Efficiency 10%
• α,β-unsaturated Aldehydes 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Heme Oxygenase 1 100%
• Crotonaldehyde 100%
• Transcription Factor Nrf2 100%
• Protein Kinase C 100%
• Small Interfering RNA 20%
• Liver Cell Carcinoma 20%
• Antiapoptotic 10%
• Fluorescence Activated Cell Sorting 10%
• Malignant Neoplasm 10%
• Cigarette Smoke 10%
• Tumor Resistance 10%
• Protoporphyrin Zinc 10%
• Aldehyde 10%
• Diseases 10%