Inducible interleukin 32 (IL-32) exerts extensive antiviral function via selective stimulation of interferon λ1 (IFN-λ1)

Yongkui Li; Jiajia Xie; Xiupeng Xu; Li Liu; Yushun Wan; Yingle Liu; Chengliang Zhu; Ying Zhu

doi:10.1074/jbc.M112.440115

Inducible interleukin 32 (IL-32) exerts extensive antiviral function via selective stimulation of interferon λ1 (IFN-λ1)

Yongkui Li
, Jiajia Xie
, Xiupeng Xu
, Li Liu
, Yushun Wan
, Yingle Liu
, Chengliang Zhu
, Ying Zhu

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Background: Interleukin-32 participates in responses to viral infection, but how virus induces its expression and the mechanisms of its antiviral activities remain unclear. Results: Interleukin-32 selectively stimulates IFN-λ1 via activating distinct regulatory elements in the promoter. Conclusion: Interleukin-32 promotes IFN-λ1-mediated antiviral response. Significance: Interleukin-32 is one immune response factor and plays an important role in the control of viral infection.

Original language	English (US)
Pages (from-to)	20927-20941
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	288
Issue number	29
DOIs	https://doi.org/10.1074/jbc.M112.440115
State	Published - Jul 19 2013
Externally published	Yes

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title = "Inducible interleukin 32 (IL-32) exerts extensive antiviral function via selective stimulation of interferon λ1 (IFN-λ1)",

abstract = "Background: Interleukin-32 participates in responses to viral infection, but how virus induces its expression and the mechanisms of its antiviral activities remain unclear. Results: Interleukin-32 selectively stimulates IFN-λ1 via activating distinct regulatory elements in the promoter. Conclusion: Interleukin-32 promotes IFN-λ1-mediated antiviral response. Significance: Interleukin-32 is one immune response factor and plays an important role in the control of viral infection.",

author = "Yongkui Li and Jiajia Xie and Xiupeng Xu and Li Liu and Yushun Wan and Yingle Liu and Chengliang Zhu and Ying Zhu",

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T1 - Inducible interleukin 32 (IL-32) exerts extensive antiviral function via selective stimulation of interferon λ1 (IFN-λ1)

AU - Li, Yongkui

AU - Xie, Jiajia

AU - Xu, Xiupeng

AU - Liu, Li

AU - Wan, Yushun

AU - Liu, Yingle

AU - Zhu, Chengliang

AU - Zhu, Ying

PY - 2013/7/19

Y1 - 2013/7/19

N2 - Background: Interleukin-32 participates in responses to viral infection, but how virus induces its expression and the mechanisms of its antiviral activities remain unclear. Results: Interleukin-32 selectively stimulates IFN-λ1 via activating distinct regulatory elements in the promoter. Conclusion: Interleukin-32 promotes IFN-λ1-mediated antiviral response. Significance: Interleukin-32 is one immune response factor and plays an important role in the control of viral infection.

AB - Background: Interleukin-32 participates in responses to viral infection, but how virus induces its expression and the mechanisms of its antiviral activities remain unclear. Results: Interleukin-32 selectively stimulates IFN-λ1 via activating distinct regulatory elements in the promoter. Conclusion: Interleukin-32 promotes IFN-λ1-mediated antiviral response. Significance: Interleukin-32 is one immune response factor and plays an important role in the control of viral infection.

UR - https://www.scopus.com/pages/publications/84880565969

UR - https://www.scopus.com/pages/publications/84880565969#tab=citedBy

U2 - 10.1074/jbc.M112.440115

DO - 10.1074/jbc.M112.440115

M3 - Article

C2 - 23729669

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SN - 0021-9258

VL - 288

SP - 20927

EP - 20941

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 29

ER -

Inducible interleukin 32 (IL-32) exerts extensive antiviral function via selective stimulation of interferon λ1 (IFN-λ1)

Abstract

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