Inducible interleukin 32 (IL-32) exerts extensive antiviral function via selective stimulation of interferon λ1 (IFN-λ1)

Yongkui Li, Jiajia Xie, Xiupeng Xu, Li Liu, Yushun Wan, Yingle Liu, Chengliang Zhu, Ying Zhu

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Background: Interleukin-32 participates in responses to viral infection, but how virus induces its expression and the mechanisms of its antiviral activities remain unclear. Results: Interleukin-32 selectively stimulates IFN-λ1 via activating distinct regulatory elements in the promoter. Conclusion: Interleukin-32 promotes IFN-λ1-mediated antiviral response. Significance: Interleukin-32 is one immune response factor and plays an important role in the control of viral infection.

Original languageEnglish (US)
Pages (from-to)20927-20941
Number of pages15
JournalJournal of Biological Chemistry
Volume288
Issue number29
DOIs
StatePublished - Jul 19 2013
Externally publishedYes

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