Induced pluripotent stem cells for neuromuscular diseases: Potential for disease modeling, drug screening, and regenerative medicine

Sridhar Selvaraj, Rita C.R. Perlingeiro

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Neuromuscular diseases are a group of acquired or inherited diseases affecting the peripheral nervous system and the skeletal muscle. The large majority of these diseases are currently incurable. Neuromuscular disease modeling is quite challenging due to the lack of appropriate human disease models. Induced pluripotent stem cell technology has not only enabled the potential to recapitulate human disease in the Petri dish, thus allowing for more specific drug screening, but also opened the opportunity for the development of autologous cell-based therapy. In this article, we will highlight major research advances and future prospects in these areas.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Tissue Engineering and Regenerative Medicine
PublisherElsevier
Pages471-481
Number of pages11
Volume1-3
ISBN (Electronic)9780128136997
ISBN (Print)9780128137000
DOIs
StatePublished - Jan 1 2019

Keywords

  • Amyotrophic lateral sclerosis
  • Charcot-marie tooth disease
  • Disease modeling
  • Drug screening
  • Induced pluripotent stem cells
  • Motor neurons
  • Muscular dystrophy
  • Neuromuscular junction
  • Peripheral neurons
  • Regenerative medicine
  • Skeletal muscle
  • Spinal muscular atrophy

Fingerprint Dive into the research topics of 'Induced pluripotent stem cells for neuromuscular diseases: Potential for disease modeling, drug screening, and regenerative medicine'. Together they form a unique fingerprint.

Cite this