Abstract
Form-fitting: The study of a minimal mimic of a protein domain that binds to type II polyproline helices through an aromatic cleft is reported. This binding motif mimics that of protein domains, including those important in disease states such as HIV infection and cancer. This study provides insight into the structure-function relationship in binding as well as quantitative data on the magnitude of prolyl-π interactions relevant to inhibitor design.
Original language | English (US) |
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Pages (from-to) | 12201-12204 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 50 |
Issue number | 51 |
DOIs | |
State | Published - Dec 16 2011 |
Externally published | Yes |
Keywords
- peptide structure
- prolyl-π interaction
- protein mimetics
- protein-protein interactions
- β hairpins