Induced-fit binding of a polyproline helix by a β-hairpin peptide

Dale J. Wilger, Jessica H. Park, Robert M. Hughes, Matthew E. Cuellar, Marcey L. Waters

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Form-fitting: The study of a minimal mimic of a protein domain that binds to type II polyproline helices through an aromatic cleft is reported. This binding motif mimics that of protein domains, including those important in disease states such as HIV infection and cancer. This study provides insight into the structure-function relationship in binding as well as quantitative data on the magnitude of prolyl-π interactions relevant to inhibitor design.

Original languageEnglish (US)
Pages (from-to)12201-12204
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number51
DOIs
StatePublished - Dec 16 2011

Keywords

  • peptide structure
  • prolyl-π interaction
  • protein mimetics
  • protein-protein interactions
  • β hairpins

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