Induced cell aggregation and mating in Streptococcus faecalis: evidence for a bacterial sex pheromone

G. M. Dunny, B. L. Brown, D. B. Clewell

Research output: Contribution to journalArticlepeer-review

319 Scopus citations

Abstract

Recipient strains of S. faecalis produce a trypsin sensitive, heat resistant, nuclease resistant factor, designated clumping-inducing agent (CIA) which causes strains carrying certain conjugative plasmids to aggregate. RNA and protein synthesis are required for aggregation to occur. Recipient filtrates that contain CIA activity also induce donors to mate at high frequencies. Introduction of a transferable plasmid into strains producing CIA dramatically reduces the amount of CIA activity produced by the strain but allows the strain to respond to exogenously added CIA. The data suggest that CIA represents a bacterial sex hormone (pheromone).

Original languageEnglish (US)
Pages (from-to)3479-3483
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume75
Issue number7
DOIs
StatePublished - 1978

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