TY - JOUR
T1 - Individualizing the use of medications in children
T2 - Making goldilocks happy
AU - Leeder, J. S.
AU - Brown, J. T.
AU - Soden, S. E.
PY - 2014/9
Y1 - 2014/9
N2 - To date, implementation of precision medicine for children has been limited. Extrapolation of adult experience streamlines pediatric drug development programs, and physiologically based pharmacokinetic models aid pediatric dose selection on a population basis. To achieve clinically viable individualization of drug therapy, genotype-stratified pharmacokinetic studies can efficiently characterize the extremes of the dose-exposure relationship. Reducing variability in exposure through genotype-based dosing may improve identification of genetic factors contributing to response, ultimately improving drug therapy for children.
AB - To date, implementation of precision medicine for children has been limited. Extrapolation of adult experience streamlines pediatric drug development programs, and physiologically based pharmacokinetic models aid pediatric dose selection on a population basis. To achieve clinically viable individualization of drug therapy, genotype-stratified pharmacokinetic studies can efficiently characterize the extremes of the dose-exposure relationship. Reducing variability in exposure through genotype-based dosing may improve identification of genetic factors contributing to response, ultimately improving drug therapy for children.
UR - http://www.scopus.com/inward/record.url?scp=84907875737&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907875737&partnerID=8YFLogxK
U2 - 10.1038/clpt.2014.130
DO - 10.1038/clpt.2014.130
M3 - Article
C2 - 24926777
AN - SCOPUS:84907875737
SN - 0009-9236
VL - 96
SP - 304
EP - 306
JO - Clinical pharmacology and therapeutics
JF - Clinical pharmacology and therapeutics
IS - 3
ER -