Individualized immunoglobulin therapy in chronic immune-mediated peripheral neuropathies*

Jeffrey A. Allen, Melvin Berger, Luis Querol, Krista Kuitwaard, Robert D. Hadden

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Despite the well-recognized importance of immunoglobulin therapy individualization during the treatment of chronic inflammatory demyelinating polyneuropathy (CIDP), the pathway to best achieve optimization is unknown. There are many pharmacokinetic and immunobiologic variables that can potentially influence the appropriateness of any individual therapy. Although identification of specific autoantibodies and their targets has only been accomplished in a minority of patients with CIDP, already the diagnostic and treatment implications of specific autoantibody detection are being realized. Individual variability in IgG pharmacokinetic properties including IgG catabolic rates and distribution, as well as the IgG level necessary for disease control also require consideration during the optimization process. For optimization to be successful there must be a measure of treatment response that has a clinically meaningful interpretation. There are currently available well-defined and validated clinical assessment tools and outcome measures that are well suited for this purpose. While there remains much to learn on how best to manipulate immunopathology and immunoglobulin pharmacokinetics in the most favorable way, there currently exists an understanding of these principles to a degree sufficient to begin to develop rational and evidence-based treatment optimization strategies.

Original languageEnglish (US)
Pages (from-to)78-87
Number of pages10
JournalJournal of the Peripheral Nervous System
Volume23
Issue number2
DOIs
StatePublished - Jun 2018

Bibliographical note

Funding Information:
1Department of Neurology, University of Minnesota, Minneapolis, MN, USA; 2Immunology Research and Development, CSL Behring, King of Prussia, PA, USA; 3Neuromuscular Diseases Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; 4Centro para la Investigación Biomédica en Red en Enfermedades Raras (CIBERER), Madrid, Spain; 5Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands; 6Department of Neurology, Albert Schweitzer Hospital, Dordrecht, The Netherlands; and 7Department of Neurology, King’s College Hospital, London, UK

Publisher Copyright:
© 2018 The Authors. Journal of the Peripheral Nervous System published by Wiley Periodicals, Inc. on behalf of Peripheral Nerve Society.

Keywords

  • autoimmune neuromuscular diseases
  • chronic inflammatory demyelinating polyneuropathy
  • immune-mediated neuropathies
  • intravenous immunoglobulin
  • pharmacokinetics

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