Individualized Functional Subnetworks Connect Human Striatum and Frontal Cortex

Evan M. Gordon, Timothy O. Laumann, Scott Marek, Dillan J. Newbold, Jacqueline M. Hampton, Nicole A. Seider, David F. Montez, Ashley M. Nielsen, Andrew N. Van, Annie Zheng, Ryland Miller, Joshua S. Siegel, Benjamin P. Kay, Abraham Z. Snyder, Deanna J. Greene, Bradley L. Schlaggar, Steven E. Petersen, Steven M. Nelson, Nico U.F. Dosenbach

Research output: Contribution to journalArticlepeer-review

Abstract

The striatum and cerebral cortex are interconnected via multiple recurrent loops that play a major role in many neuropsychiatric conditions. Primate corticostriatal connections can be precisely mapped using invasive tract-tracing. However, noninvasive human research has not mapped these connections with anatomical precision, limited in part by the practice of averaging neuroimaging data across individuals. Here we utilized highly sampled resting-state functional connectivity MRI for individual-specific precision functional mapping (PFM) of corticostriatal connections. We identified ten individual-specific subnetworks linking cortex - predominately frontal cortex - to striatum, most of which converged with nonhuman primate tract-tracing work. These included separable connections between nucleus accumbens core/shell and orbitofrontal/medial frontal gyrus; between anterior striatum and dorsomedial prefrontal cortex; between dorsal caudate and lateral prefrontal cortex; and between middle/posterior putamen and supplementary motor/primary motor cortex. Two subnetworks that did not converge with nonhuman primates were connected to cortical regions associated with human language function. Thus, precision subnetworks identify detailed, individual-specific, neurobiologically plausible corticostriatal connectivity that includes human-specific language networks.

Original languageEnglish (US)
Pages (from-to)2868-2884
Number of pages17
JournalCerebral Cortex
Volume32
Issue number13
DOIs
StatePublished - Jul 1 2022

Bibliographical note

Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press. All rights reserved.

Keywords

  • brain networks
  • fMRI
  • functional connectivity
  • individual variability
  • striatum

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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