Individual differences in the subjective response to smoked cocaine in humans

M. Sofuoglu, S. Brown, S. Dudish-Poulsen, D. K. Hatsukami

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The individual variables that determine the effects of cocaine in humans are not well understood. In this study, we examined the relationship between the subjective response to cocaine and selected individual variables in cocaine-dependent participants. A single 0.4-mg/kg dose of smoked cocaine was received by 75 smoked cocaine users. The variables associated with increased subjective response to cocaine were male sex, presence of alcohol use, higher baseline Beck Depression Inventory (BDI) scores, and duration of cocaine use. The change in heart rate and diastolic blood pressure in response to cocaine delivery were also positively associated with the subjective response to cocaine. In contrast, body weight, years of schooling, and the change in the heart rate with the expectation of cocaine delivery were associated with a diminished subjective response to cocaine. The importance of these variables in mainreining the cocaine use behavior needs to be studied further.

Original languageEnglish (US)
Pages (from-to)591-602
Number of pages12
JournalAmerican Journal of Drug and Alcohol Abuse
Issue number4
StatePublished - 2000

Bibliographical note

Funding Information:
This research was supported by grants from the National Institute on Drug Abuse (P-50 DA09259) and from the National Center for Research Resources (MO1-RR00400). We would like to thank David Babb and the General Clinical Research Center nursing staff for technical assistance.


  • Cocaine
  • Crack cocaine
  • Subjective response

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