@article{69ff416ce4164024b32c8e5fcb4ab244,
title = "Increasing Incidence of Chronic Graft-versus-Host Disease inAllogeneic Transplantation: A Report from the Center for International Blood and Marrow Transplant Research",
abstract = "Although transplant practices have changed over the last decades, no information is available on trends in incidence and outcome of chronic graft-versus-host disease (cGVHD) over time. This study used the central database of the Center for International Blood and Marrow Transplant Research (CIBMTR) to describe time trends for cGVHD incidence, nonrelapse mortality, and risk factors for cGVHD. The 12-year period was divided into 3 intervals, 1995 to 1999, 2000 to 2003, and 2004 to 2007, and included 26,563 patients with acute leukemia, chronic myeloid leukemia, and myelodysplastic syndrome. Multivariate analysis showed an increased incidence of cGVHD in more recent years (odds ratio=1.19, P<.0001), and this trend was still seen when adjusting for donor type, graft type, or conditioning intensity. In patients with cGVHD, nonrelapse mortality has decreased over time, but at 5years there were no significant differences among different time periods. Risk factors for cGVHD were in line with previous studies. This is the first comprehensive characterization of the trends in cGVHD incidence and underscores the mounting need for addressing this major late complication of transplantation in future research.",
keywords = "Allogeneic transplant, CGVHD, Incidence, Nonrelapse mortality",
author = "Sally Arai and Mukta Arora and Tao Wang and Spellman, {Stephen R.} and Wensheng He and Couriel, {Daniel R.} and Alvaro Urbano-Ispizua and Cutler, {Corey S.} and Bacigalupo, {Andrea A.} and Minoo Battiwalla and Flowers, {Mary E.} and Juckett, {Mark B.} and Lee, {Stephanie J.} and Loren, {Alison W.} and Klumpp, {Thomas R.} and Prockup, {Susan E.} and Ringd{\'e}n, {Olle T H} and Savani, {Bipin N.} and G{\'e}rard Soci{\'e} and Schultz, {Kirk R.} and Thomas Spitzer and Takanori Teshima and Bredeson, {Christopher N.} and Jacobsohn, {David A.} and Hayashi, {Robert J.} and Drobyski, {William R.} and Frangoul, {Haydar A.} and G{\"o}rg{\"u}n Akpek and Ho, {Vincent T.} and Lewis, {Victor A.} and Gale, {Robert Peter} and John Koreth and Chao, {Nelson J.} and Aljurf, {Mahmoud D.} and Cooper, {Brenda W.} and Laughlin, {Mary J.} and Hsu, {Jack W.} and Peiman Hematti and Verdonck, {Leo F.} and Solh, {Melhelm M.} and Maxim Norkin and Vijay Reddy and Rodrigo Martino and Shahinaz Gadalla and Goldberg, {Jenna D.} and McCarthy, {Philip L.} and P{\'e}rez-Sim{\'o}n, {Jos{\'e} A.} and Nandita Khera and Lewis, {Ian D.} and Yoshiko Atsuta and Olsson, {Richard F.} and Wael Saber and Waller, {Edmund K.} and Didier Blaise and Pidala, {Joseph A.} and Martin, {Paul J.} and Prakash Satwani and Martin Bornh{\"a}user and Yoshihiro Inamoto and Weisdorf, {Daniel J.} and Horowitz, {Mary M.} and Pavletic, {Steven Z.}",
note = "Publisher Copyright: {\textcopyright} 2015 American Society for Blood and Marrow Transplantation.",
year = "2015",
month = feb,
day = "1",
doi = "10.1016/j.bbmt.2014.10.021",
language = "English (US)",
volume = "21",
pages = "266--274",
journal = "Biology of Blood and Marrow Transplantation",
issn = "1083-8791",
publisher = "Elsevier Inc.",
number = "2",
}
