Increased Sympathetic Activity in Cirrhosis

Helmer Ring-Larsen, Jens H. Henriksen, Niels Juel Christensen, Steven Goldsmith, Murray Epstein, Mortimer Levy, Daniel G. Bichet, Vicki J. Van Putten, Robert W. Schrier, Franklin H. Epstein

Research output: Contribution to journalLetterpeer-review

25 Scopus citations


To the Editor: Like Bichet et al. (Dec. 16 issue)1 we have recently observed that sympathetic nervous activity, as assessed by the plasma norepinephrine concentration, is dramatically increased in decompensated cirrhosis.2 Since the kidney releases norepinephrine into the peripheral circulation in this condition,2 we have suggested that increased sympathetic nervous activity may be of importance in the renal cortical vasoconstriction in decompensated cirrhosis.3 The results reported by Bichet et al. support the view that the sympathetic nervous system is an important component of the homeostatic mechanisms in advanced liver disease. These authors observed a relation between the plasma norepinephrine level,.

Original languageEnglish (US)
Pages (from-to)1029-1032
Number of pages4
JournalNew England Journal of Medicine
Issue number17
StatePublished - Apr 28 1983


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