Increased skeletal muscle acetylcholinesterase activity in porcine malignant hyperthermia

James R. Mickelson, Hemant S. Thatte, Terrrence M. Beaudry, Esther M. Gallant, Charles F. Louis

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The content and distribution of acetylcholinesterase (AChE) activity in the skeletal muscle disorder malignant hyperthermia (MH) was examined. The AChE activity of sarcolemma membranes isolated from MH‐susceptible (MHS) swine was increased twofold when compared with normal sarcolemma. The total AChE activity of muscle extracts was also doubled in MHS tissue; however, the relative distribution between low‐salt extractable (globular forms) and high‐salt extractable (asymmetric forms) AChE activities were similar in MHS and normal muscle. Our results suggest that, for as yet unexplained reasons, both the sarcolemmal and total AChE activity of skeletal muscle is increased in porcine MH.

Original languageEnglish (US)
Pages (from-to)723-727
Number of pages5
JournalMuscle & Nerve
Volume10
Issue number8
DOIs
StatePublished - Oct 1987

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