Increased REM sleep without atonia in Parkinson disease with freezing of gait

A. Videnovic, C. Marlin, L. Alibiglou, P. J. Planetta, D. E. Vaillancourt, Colum MacKinnon

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective: The objective of this cross-sectional study was to test the hypothesis that patients with Parkinson disease (PD) and freezing of gait (PD+FOG) would demonstrate sleep disturbances comparable to those seen in patients with REM sleep behavior disorder (RBD) and these changes would be significantly different from those in PD patients without FOG (PD-FOG) and agematched controls. Methods: We conducted overnight polysomnography studies in 4 groups of subjects: RBD, PD-FOG, PD+FOG, and controls. Tonic and phasic muscle activity during REM sleep were quantified using EMG recordings from the chin, compared among study groups, and correlated with disease metrics. Results: There were no significant differences in measures of disease severity, duration, or dopaminergic medications between the PD+FOG and PD-FOG groups. Tonic muscle activity was increased significantly (p < 0.007) in the RBD and PD+FOG groups compared to the PD-FOG and control groups. There was no significant difference in tonic EMG between the PD+FOG and RBD group (p = 0.364), or in tonic or phasic EMG between the PD-FOG and control group (p = 0.107). Phasic muscle activity was significantly increased in the RBD group compared to all other groups (p = 0.029) and between the PD+FOG and control group (p = 0.001), but not between the PD+FOG and PD-FOG groups (p = 0.059). Conclusions: These findings provide evidence that increased muscle activity during REM sleep is a comorbid feature of patients with PD who exhibit FOG as a motor manifestation of their disease.

Original languageEnglish (US)
Pages (from-to)1030-1035
Number of pages6
JournalNeurology
Volume81
Issue number12
DOIs
StatePublished - Sep 17 2013

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REM Sleep
Gait
Freezing
Parkinson Disease
REM Sleep Behavior Disorder
Muscles
Control Groups
Chin
Polysomnography

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Videnovic, A., Marlin, C., Alibiglou, L., Planetta, P. J., Vaillancourt, D. E., & MacKinnon, C. (2013). Increased REM sleep without atonia in Parkinson disease with freezing of gait. Neurology, 81(12), 1030-1035. https://doi.org/10.1212/WNL.0b013e3182a4a408

Increased REM sleep without atonia in Parkinson disease with freezing of gait. / Videnovic, A.; Marlin, C.; Alibiglou, L.; Planetta, P. J.; Vaillancourt, D. E.; MacKinnon, Colum.

In: Neurology, Vol. 81, No. 12, 17.09.2013, p. 1030-1035.

Research output: Contribution to journalArticle

Videnovic, A, Marlin, C, Alibiglou, L, Planetta, PJ, Vaillancourt, DE & MacKinnon, C 2013, 'Increased REM sleep without atonia in Parkinson disease with freezing of gait', Neurology, vol. 81, no. 12, pp. 1030-1035. https://doi.org/10.1212/WNL.0b013e3182a4a408
Videnovic A, Marlin C, Alibiglou L, Planetta PJ, Vaillancourt DE, MacKinnon C. Increased REM sleep without atonia in Parkinson disease with freezing of gait. Neurology. 2013 Sep 17;81(12):1030-1035. https://doi.org/10.1212/WNL.0b013e3182a4a408
Videnovic, A. ; Marlin, C. ; Alibiglou, L. ; Planetta, P. J. ; Vaillancourt, D. E. ; MacKinnon, Colum. / Increased REM sleep without atonia in Parkinson disease with freezing of gait. In: Neurology. 2013 ; Vol. 81, No. 12. pp. 1030-1035.
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AU - MacKinnon, Colum

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N2 - Objective: The objective of this cross-sectional study was to test the hypothesis that patients with Parkinson disease (PD) and freezing of gait (PD+FOG) would demonstrate sleep disturbances comparable to those seen in patients with REM sleep behavior disorder (RBD) and these changes would be significantly different from those in PD patients without FOG (PD-FOG) and agematched controls. Methods: We conducted overnight polysomnography studies in 4 groups of subjects: RBD, PD-FOG, PD+FOG, and controls. Tonic and phasic muscle activity during REM sleep were quantified using EMG recordings from the chin, compared among study groups, and correlated with disease metrics. Results: There were no significant differences in measures of disease severity, duration, or dopaminergic medications between the PD+FOG and PD-FOG groups. Tonic muscle activity was increased significantly (p < 0.007) in the RBD and PD+FOG groups compared to the PD-FOG and control groups. There was no significant difference in tonic EMG between the PD+FOG and RBD group (p = 0.364), or in tonic or phasic EMG between the PD-FOG and control group (p = 0.107). Phasic muscle activity was significantly increased in the RBD group compared to all other groups (p = 0.029) and between the PD+FOG and control group (p = 0.001), but not between the PD+FOG and PD-FOG groups (p = 0.059). Conclusions: These findings provide evidence that increased muscle activity during REM sleep is a comorbid feature of patients with PD who exhibit FOG as a motor manifestation of their disease.

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