Increased platelet response to ADP-stimulation in vitro in peripheral arterial occlusive disease after treadmill exercise

S. Vanderschueren, J. Philippe, M. De Buyzere, D. Duprez, G. Leroux-Roels

Research output: Contribution to journalArticlepeer-review

Abstract

In patients with peripheral arterial occlusive disease (PAOD) increased plasma concentrations of platelet secretion products, particularly after treadmill exercise, suggest platelet activation. In the present study, we used flow cytometry to obtain data on the effects of a standardized treadmill exercise on platelet activation in vitro after ADP-stimulation in PAOD patients. GMP-140 (CD62), a secretion dependent alpha granule membrane protein, was used as platelet activation marker. Nineteen PAOD patients and 7 controls were included in the study. There was no difference in response to ADP-stimulation in vitro between controls and PAOD patients. However, treadmill exercise caused a significant increase (p = 0.03) in platelet response to ADP-stimulation in vitro (from 77.3 ± 13.3 to 79.5 ± 13.4%).

Original languageEnglish (US)
Pages (from-to)57-59
Number of pages3
JournalThrombotic and Haemorrhagic Disorders
Volume8
Issue number2
StatePublished - Dec 1 1993

Keywords

  • flow cytometry
  • peripheral arterial occlusive disease
  • platelet activation
  • treadmill exercise

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