Increased phosphorylation of nuclear phosphoproteins in precancerous liver

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An increase in the rate of phosphorylation of nuclear phosphoproteins, as measured by the in vitro transfer of 32P from [γ-32P]ATP into isolated nuclei, was observed in nuclei derived from livers of animals fed on a diet containing 3' methyl 4 dimethylaminoazobenzene compared with those from normal livers. The increase in the phosphorylation of nuclear phosphoproteins occurred in the early hyperplastic response prior to the formation of hepatoma.

Original languageEnglish (US)
Pages (from-to)771-774
Number of pages4
Issue number4
StatePublished - Dec 1 1974


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