Increased minimum inhibitory concentrations with anaerobiasis for tobramycin, gentamicin, and amikacin, compared to latamoxef, piperacillin, chloramphenicol, and clindamycin.

K. J. Tack, L. D. Sabath

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Minimum inhibitory concentrations (MICs) were determined under both routine aerobic and anaerobic conditions for a total of 93 organisms representing nine genera. MICs for the aminoglycosides amikacin, gentamicin, and tobramycin were significantly increased under anaerobic conditions. Tobramycin was most sensitive to the loss of antimicrobial activity with anaerobiasis. MICs for staphylococci were increased by a higher factor than were MICs for gram-negative rods, but even within the latter group increases in MICs for Proteus species were greater than for Salmonella, Klebsiella and Escherichia coli. No change of anaerobic versus aerobic activity was seen for latamoxef, piperacillin, chloramphenicol, or clindamycin.
Original languageUndefined/Unknown
Pages (from-to)204-210
Number of pages7
JournalChemotherapy
Volume31
Issue number3
StatePublished - 1985

Keywords

  • Amikacin/pd [Pharmacology]
  • Aminoglycosides/pd [Pharmacology]
  • Anaerobiosis
  • Anti-Bacterial Agents/pd [Pharmacology]
  • Chloramphenicol/pd [Pharmacology]
  • Clindamycin/pd [Pharmacology]
  • Enterobacter/de [Drug Effects]
  • Escherichia coli/de [Drug Effects]
  • Gentamicins/pd [Pharmacology]
  • Humans
  • Klebsiella/de [Drug Effects]
  • Microbial Sensitivity Tests
  • Moxalactam/pd [Pharmacology]
  • Piperacillin/pd [Pharmacology]
  • Salmonella/de [Drug Effects]
  • Serratia/de [Drug Effects]
  • Staphylococcus/de [Drug Effects]
  • Streptococcus/de [Drug Effects]
  • Tobramycin/pd [Pharmacology]

Cite this

@article{5a88c08dfa5047b695d41ab3f39ade2e,
title = "Increased minimum inhibitory concentrations with anaerobiasis for tobramycin, gentamicin, and amikacin, compared to latamoxef, piperacillin, chloramphenicol, and clindamycin.",
abstract = "Minimum inhibitory concentrations (MICs) were determined under both routine aerobic and anaerobic conditions for a total of 93 organisms representing nine genera. MICs for the aminoglycosides amikacin, gentamicin, and tobramycin were significantly increased under anaerobic conditions. Tobramycin was most sensitive to the loss of antimicrobial activity with anaerobiasis. MICs for staphylococci were increased by a higher factor than were MICs for gram-negative rods, but even within the latter group increases in MICs for Proteus species were greater than for Salmonella, Klebsiella and Escherichia coli. No change of anaerobic versus aerobic activity was seen for latamoxef, piperacillin, chloramphenicol, or clindamycin.",
keywords = "Amikacin/pd [Pharmacology], Aminoglycosides/pd [Pharmacology], Anaerobiosis, Anti-Bacterial Agents/pd [Pharmacology], Chloramphenicol/pd [Pharmacology], Clindamycin/pd [Pharmacology], Enterobacter/de [Drug Effects], Escherichia coli/de [Drug Effects], Gentamicins/pd [Pharmacology], Humans, Klebsiella/de [Drug Effects], Microbial Sensitivity Tests, Moxalactam/pd [Pharmacology], Piperacillin/pd [Pharmacology], Salmonella/de [Drug Effects], Serratia/de [Drug Effects], Staphylococcus/de [Drug Effects], Streptococcus/de [Drug Effects], Tobramycin/pd [Pharmacology]",
author = "Tack, {K. J.} and Sabath, {L. D.}",
year = "1985",
language = "Undefined/Unknown",
volume = "31",
pages = "204--210",
journal = "Chemotherapy",
issn = "0009-3157",
publisher = "S. Karger AG",
number = "3",

}

TY - JOUR

T1 - Increased minimum inhibitory concentrations with anaerobiasis for tobramycin, gentamicin, and amikacin, compared to latamoxef, piperacillin, chloramphenicol, and clindamycin.

AU - Tack, K. J.

AU - Sabath, L. D.

PY - 1985

Y1 - 1985

N2 - Minimum inhibitory concentrations (MICs) were determined under both routine aerobic and anaerobic conditions for a total of 93 organisms representing nine genera. MICs for the aminoglycosides amikacin, gentamicin, and tobramycin were significantly increased under anaerobic conditions. Tobramycin was most sensitive to the loss of antimicrobial activity with anaerobiasis. MICs for staphylococci were increased by a higher factor than were MICs for gram-negative rods, but even within the latter group increases in MICs for Proteus species were greater than for Salmonella, Klebsiella and Escherichia coli. No change of anaerobic versus aerobic activity was seen for latamoxef, piperacillin, chloramphenicol, or clindamycin.

AB - Minimum inhibitory concentrations (MICs) were determined under both routine aerobic and anaerobic conditions for a total of 93 organisms representing nine genera. MICs for the aminoglycosides amikacin, gentamicin, and tobramycin were significantly increased under anaerobic conditions. Tobramycin was most sensitive to the loss of antimicrobial activity with anaerobiasis. MICs for staphylococci were increased by a higher factor than were MICs for gram-negative rods, but even within the latter group increases in MICs for Proteus species were greater than for Salmonella, Klebsiella and Escherichia coli. No change of anaerobic versus aerobic activity was seen for latamoxef, piperacillin, chloramphenicol, or clindamycin.

KW - Amikacin/pd [Pharmacology]

KW - Aminoglycosides/pd [Pharmacology]

KW - Anaerobiosis

KW - Anti-Bacterial Agents/pd [Pharmacology]

KW - Chloramphenicol/pd [Pharmacology]

KW - Clindamycin/pd [Pharmacology]

KW - Enterobacter/de [Drug Effects]

KW - Escherichia coli/de [Drug Effects]

KW - Gentamicins/pd [Pharmacology]

KW - Humans

KW - Klebsiella/de [Drug Effects]

KW - Microbial Sensitivity Tests

KW - Moxalactam/pd [Pharmacology]

KW - Piperacillin/pd [Pharmacology]

KW - Salmonella/de [Drug Effects]

KW - Serratia/de [Drug Effects]

KW - Staphylococcus/de [Drug Effects]

KW - Streptococcus/de [Drug Effects]

KW - Tobramycin/pd [Pharmacology]

M3 - Article

VL - 31

SP - 204

EP - 210

JO - Chemotherapy

JF - Chemotherapy

SN - 0009-3157

IS - 3

ER -