Increased levels of laminin in ascitic fluid of patients with ovarian cancer

Lowell J. Byers; Janet L. Osborne; Linda F Carson; Jonathan R. Carter; A. F. Haney; J. Brice Weinberg; Sundaram Ramakrishnan

doi:10.1016/0304-3835(94)03625-S

Increased levels of laminin in ascitic fluid of patients with ovarian cancer

Lowell J. Byers, Janet L. Osborne, Linda F Carson, Jonathan R. Carter, A. F. Haney, J. Brice Weinberg, Sundaram Ramakrishnan

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Abstract

Laminin is a component of the extracellular matrix and is associated with tumor cell metastasis. Present studies show that the ovarian cancer cell lines produce significant amounts of laminin (54-140 ng/ml) in culture. Since ovarian cancer is associated with ascites production, laminin levels were then determined in ascites and serum. The results indicate that the ascites from patients with serous adenocarcinoma of the ovary had higher levels of laminin than the normal peritoneal fluid (P < 0.0001). However, the serum levels of laminin did not differ significantly between the control population and ovarian cancer patients.

Original language	English (US)
Pages (from-to)	67-72
Number of pages	6
Journal	Cancer Letters
Volume	88
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(94)03625-S
State	Published - Jan 6 1995

Bibliographical note

Funding Information:
Funding for this studyw as providedi n part by grantsf rom NIH, CA 48068a nd the Women’s CancerC entero f the Universityo f Minnesota.

Keywords

Ascites
Laminin
Metastasis
Ovarian carcinoma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0304-3835(94)03625-S

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title = "Increased levels of laminin in ascitic fluid of patients with ovarian cancer",

abstract = "Laminin is a component of the extracellular matrix and is associated with tumor cell metastasis. Present studies show that the ovarian cancer cell lines produce significant amounts of laminin (54-140 ng/ml) in culture. Since ovarian cancer is associated with ascites production, laminin levels were then determined in ascites and serum. The results indicate that the ascites from patients with serous adenocarcinoma of the ovary had higher levels of laminin than the normal peritoneal fluid (P < 0.0001). However, the serum levels of laminin did not differ significantly between the control population and ovarian cancer patients.",

keywords = "Ascites, Laminin, Metastasis, Ovarian carcinoma",

author = "Byers, {Lowell J.} and Osborne, {Janet L.} and Carson, {Linda F} and Carter, {Jonathan R.} and Haney, {A. F.} and Weinberg, {J. Brice} and Sundaram Ramakrishnan",

note = "Funding Information: Funding for this studyw as providedi n part by grantsf rom NIH, CA 48068a nd the Women{\textquoteright}s CancerC entero f the Universityo f Minnesota.",

year = "1995",

month = jan,

day = "6",

doi = "10.1016/0304-3835(94)03625-S",

language = "English (US)",

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pages = "67--72",

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TY - JOUR

T1 - Increased levels of laminin in ascitic fluid of patients with ovarian cancer

AU - Byers, Lowell J.

AU - Osborne, Janet L.

AU - Carson, Linda F

AU - Carter, Jonathan R.

AU - Haney, A. F.

AU - Weinberg, J. Brice

AU - Ramakrishnan, Sundaram

N1 - Funding Information: Funding for this studyw as providedi n part by grantsf rom NIH, CA 48068a nd the Women’s CancerC entero f the Universityo f Minnesota.

PY - 1995/1/6

Y1 - 1995/1/6

N2 - Laminin is a component of the extracellular matrix and is associated with tumor cell metastasis. Present studies show that the ovarian cancer cell lines produce significant amounts of laminin (54-140 ng/ml) in culture. Since ovarian cancer is associated with ascites production, laminin levels were then determined in ascites and serum. The results indicate that the ascites from patients with serous adenocarcinoma of the ovary had higher levels of laminin than the normal peritoneal fluid (P < 0.0001). However, the serum levels of laminin did not differ significantly between the control population and ovarian cancer patients.

AB - Laminin is a component of the extracellular matrix and is associated with tumor cell metastasis. Present studies show that the ovarian cancer cell lines produce significant amounts of laminin (54-140 ng/ml) in culture. Since ovarian cancer is associated with ascites production, laminin levels were then determined in ascites and serum. The results indicate that the ascites from patients with serous adenocarcinoma of the ovary had higher levels of laminin than the normal peritoneal fluid (P < 0.0001). However, the serum levels of laminin did not differ significantly between the control population and ovarian cancer patients.

KW - Ascites

KW - Laminin

KW - Metastasis

KW - Ovarian carcinoma

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AN - SCOPUS:0028860136

SN - 0304-3835

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JO - Cancer Letters

JF - Cancer Letters

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ER -

Increased levels of laminin in ascitic fluid of patients with ovarian cancer

Abstract

Bibliographical note

Keywords

UN SDGs

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