INCREASED INCIDENCE OF MALIGNANCY DURING CHRONIC RENAL FAILURE

ArthurJ Matas, CarlM Kjellstrand, RichardL Simmons, TheodoreJ Buselmeier, JohnS Najarian

Research output: Contribution to journalArticlepeer-review

272 Scopus citations

Abstract

The incidence of cancer in 646 dialysis/ transplant patients before uræmia developed, during the period of progressive uræmia, and post-transplantation was compared. 10 tumours (3 breast, 2 kidney, 1 leukæmia, 1 lung, 1 insulinoma, 1 thyroid, 1 cervix in situ) developed in 9 patients during the period of progressive uræmia, a significant increase over the expected number in the age-matched general population. 6 of these patients have received transplants and have no evidence of recurrent disease 6 months to 4 years post-transplantation. 11 de-novo tumours have developed in 530 transplant recipients (4 cervix in situ, 2 skin, 2 reticulum-cell sarcoma, 1 lip, 1 dysgerminoma, 1 colon)-a significant increase over the age-matched general population. The cancers in the uræmic patients are relatively common types of mesenchymal tumours while the cancers in the transplant recipients are epithelial and lymphoproliferative. This difference may reflect the presence of the graft in the transplant patient or may be due to different patterns of immunosuppression in these two populations.

Original languageEnglish (US)
Pages (from-to)883-886
Number of pages4
JournalThe Lancet
Volume305
Issue number7912
DOIs
StatePublished - Apr 19 1975

Bibliographical note

Funding Information:
This work was supported by grant Public Health Service.

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

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