TY - JOUR
T1 - INCREASED INCIDENCE OF MALIGNANCY DURING CHRONIC RENAL FAILURE
AU - Matas, ArthurJ
AU - Kjellstrand, CarlM
AU - Simmons, RichardL
AU - Buselmeier, TheodoreJ
AU - Najarian, JohnS
N1 - Funding Information:
This work was supported by grant Public Health Service.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1975/4/19
Y1 - 1975/4/19
N2 - The incidence of cancer in 646 dialysis/ transplant patients before uræmia developed, during the period of progressive uræmia, and post-transplantation was compared. 10 tumours (3 breast, 2 kidney, 1 leukæmia, 1 lung, 1 insulinoma, 1 thyroid, 1 cervix in situ) developed in 9 patients during the period of progressive uræmia, a significant increase over the expected number in the age-matched general population. 6 of these patients have received transplants and have no evidence of recurrent disease 6 months to 4 years post-transplantation. 11 de-novo tumours have developed in 530 transplant recipients (4 cervix in situ, 2 skin, 2 reticulum-cell sarcoma, 1 lip, 1 dysgerminoma, 1 colon)-a significant increase over the age-matched general population. The cancers in the uræmic patients are relatively common types of mesenchymal tumours while the cancers in the transplant recipients are epithelial and lymphoproliferative. This difference may reflect the presence of the graft in the transplant patient or may be due to different patterns of immunosuppression in these two populations.
AB - The incidence of cancer in 646 dialysis/ transplant patients before uræmia developed, during the period of progressive uræmia, and post-transplantation was compared. 10 tumours (3 breast, 2 kidney, 1 leukæmia, 1 lung, 1 insulinoma, 1 thyroid, 1 cervix in situ) developed in 9 patients during the period of progressive uræmia, a significant increase over the expected number in the age-matched general population. 6 of these patients have received transplants and have no evidence of recurrent disease 6 months to 4 years post-transplantation. 11 de-novo tumours have developed in 530 transplant recipients (4 cervix in situ, 2 skin, 2 reticulum-cell sarcoma, 1 lip, 1 dysgerminoma, 1 colon)-a significant increase over the age-matched general population. The cancers in the uræmic patients are relatively common types of mesenchymal tumours while the cancers in the transplant recipients are epithelial and lymphoproliferative. This difference may reflect the presence of the graft in the transplant patient or may be due to different patterns of immunosuppression in these two populations.
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U2 - 10.1016/S0140-6736(75)91684-0
DO - 10.1016/S0140-6736(75)91684-0
M3 - Article
C2 - 47534
AN - SCOPUS:0016856729
VL - 305
SP - 883
EP - 886
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 7912
ER -