Increased incidence of diabetes mellitus in relation to abdominal adiposity in older women

Susan A. Kaye; Aaron R. Folsom; J. Michael Sprafka; Ronald J. Prineas; Robert B. Wallace

doi:10.1016/0895-4356(91)90044-A

Increased incidence of diabetes mellitus in relation to abdominal adiposity in older women

Susan A. Kaye, Aaron R. Folsom, J. Michael Sprafka, Ronald J. Prineas, Robert B. Wallace

Epidemiology & Community Health

Research output: Contribution to journal › Article › peer-review

158 Scopus citations

Abstract

The relationship between body fat distribution, measured by the ratio of waist-to-hip circumferences (WHR), and the 2 year incidence of diabetes mellitus was examined in a cohort of 41,837 women aged 55-69 years. The 399 women who reported the new onset of diabetes had a significantly greater mean body mass index (kg/m²) and WHR than non-cases. After adjustment for body mass index (BMI), age and education level using multivariate logistic regression, WHR was a significant independent predictor of diabetes in a dose-response fashion. Cases were 4.6 times (95% CI = 3.8, 5.6) more likely than non-cases to be in the upper tertile of WHR and 2.2 times (95% CI = 1.8, 2.7) more likely to be in the middle tertile. Women in the highest tertiles of both WHR and BMI had a 14.4-fold (95% CI = 9.5, 21.9) higher risk of diabetes than women in the lowest tertiles. These results demonstrate that increased abdominal adiposity is a significant independent risk factor for the development of diabetes mellitus in older women.

Original language	English (US)
Pages (from-to)	329-334
Number of pages	6
Journal	Journal of Clinical Epidemiology
Volume	44
Issue number	3
DOIs	https://doi.org/10.1016/0895-4356(91)90044-A
State	Published - 1991

Bibliographical note

Funding Information:
Acknowledgements-The authors would like to thank Linh Pham, Joonho Kim, Susan Gapstur, Karen Johnson and Joyce Wenz for their contributions and Laura Kemmis for manuscript preparation. This work is supported by a grant from the National Cancer Institute (ROI CA39742).

Keywords

Body weight
Diabetes mellitus
Fat distribution
Obesity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0895-4356(91)90044-A

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title = "Increased incidence of diabetes mellitus in relation to abdominal adiposity in older women",

abstract = "The relationship between body fat distribution, measured by the ratio of waist-to-hip circumferences (WHR), and the 2 year incidence of diabetes mellitus was examined in a cohort of 41,837 women aged 55-69 years. The 399 women who reported the new onset of diabetes had a significantly greater mean body mass index (kg/m2) and WHR than non-cases. After adjustment for body mass index (BMI), age and education level using multivariate logistic regression, WHR was a significant independent predictor of diabetes in a dose-response fashion. Cases were 4.6 times (95% CI = 3.8, 5.6) more likely than non-cases to be in the upper tertile of WHR and 2.2 times (95% CI = 1.8, 2.7) more likely to be in the middle tertile. Women in the highest tertiles of both WHR and BMI had a 14.4-fold (95% CI = 9.5, 21.9) higher risk of diabetes than women in the lowest tertiles. These results demonstrate that increased abdominal adiposity is a significant independent risk factor for the development of diabetes mellitus in older women.",

keywords = "Body weight, Diabetes mellitus, Fat distribution, Obesity",

author = "Kaye, {Susan A.} and Folsom, {Aaron R.} and Sprafka, {J. Michael} and Prineas, {Ronald J.} and Wallace, {Robert B.}",

note = "Funding Information: Acknowledgements-The authors would like to thank Linh Pham, Joonho Kim, Susan Gapstur, Karen Johnson and Joyce Wenz for their contributions and Laura Kemmis for manuscript preparation. This work is supported by a grant from the National Cancer Institute (ROI CA39742).",

year = "1991",

doi = "10.1016/0895-4356(91)90044-A",

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AU - Kaye, Susan A.

AU - Folsom, Aaron R.

AU - Sprafka, J. Michael

AU - Prineas, Ronald J.

AU - Wallace, Robert B.

N1 - Funding Information: Acknowledgements-The authors would like to thank Linh Pham, Joonho Kim, Susan Gapstur, Karen Johnson and Joyce Wenz for their contributions and Laura Kemmis for manuscript preparation. This work is supported by a grant from the National Cancer Institute (ROI CA39742).

PY - 1991

Y1 - 1991

N2 - The relationship between body fat distribution, measured by the ratio of waist-to-hip circumferences (WHR), and the 2 year incidence of diabetes mellitus was examined in a cohort of 41,837 women aged 55-69 years. The 399 women who reported the new onset of diabetes had a significantly greater mean body mass index (kg/m2) and WHR than non-cases. After adjustment for body mass index (BMI), age and education level using multivariate logistic regression, WHR was a significant independent predictor of diabetes in a dose-response fashion. Cases were 4.6 times (95% CI = 3.8, 5.6) more likely than non-cases to be in the upper tertile of WHR and 2.2 times (95% CI = 1.8, 2.7) more likely to be in the middle tertile. Women in the highest tertiles of both WHR and BMI had a 14.4-fold (95% CI = 9.5, 21.9) higher risk of diabetes than women in the lowest tertiles. These results demonstrate that increased abdominal adiposity is a significant independent risk factor for the development of diabetes mellitus in older women.

AB - The relationship between body fat distribution, measured by the ratio of waist-to-hip circumferences (WHR), and the 2 year incidence of diabetes mellitus was examined in a cohort of 41,837 women aged 55-69 years. The 399 women who reported the new onset of diabetes had a significantly greater mean body mass index (kg/m2) and WHR than non-cases. After adjustment for body mass index (BMI), age and education level using multivariate logistic regression, WHR was a significant independent predictor of diabetes in a dose-response fashion. Cases were 4.6 times (95% CI = 3.8, 5.6) more likely than non-cases to be in the upper tertile of WHR and 2.2 times (95% CI = 1.8, 2.7) more likely to be in the middle tertile. Women in the highest tertiles of both WHR and BMI had a 14.4-fold (95% CI = 9.5, 21.9) higher risk of diabetes than women in the lowest tertiles. These results demonstrate that increased abdominal adiposity is a significant independent risk factor for the development of diabetes mellitus in older women.

KW - Body weight

KW - Diabetes mellitus

KW - Fat distribution

KW - Obesity

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Increased incidence of diabetes mellitus in relation to abdominal adiposity in older women

Abstract

Bibliographical note

Keywords

UN SDGs

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