Increased hexosaminidase activity in antipsychotic-induced extrapyramidal side effects: Possible association with higher occurrence in bipolar disorder patients

Zeliha Tunca; Halil Resmi; H. Asuman Ozkara; Gönenc Ciliv; Basak Celtikci; Koksal Alptekin; Aysegul Ozerdem; Berna Kivircik Akdede; Burak Baykara; Bilge Birsoy; Gul Ergor

doi:10.1016/j.pnpbp.2008.03.008

Increased hexosaminidase activity in antipsychotic-induced extrapyramidal side effects: Possible association with higher occurrence in bipolar disorder patients

Zeliha Tunca, Halil Resmi, H. Asuman Ozkara, Gönenc Ciliv, Basak Celtikci, Koksal Alptekin, Aysegul Ozerdem, Berna Kivircik Akdede, Burak Baykara, Bilge Birsoy, Gul Ergor

The Hormel Institute

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1 Scopus citations

Abstract

Dystonic movements and Parkinsonism are frequently seen in gangliosidoses and these conditions have been reported to modify dopaminergic plasticity. We investigated whether the activity of hexosaminidase, a type-two ganglioside (GM2) degrading enzyme, correlates with drug-induced extrapyramidal system (EPS) side effects in psychiatric patients. We compared hexosaminidase activity in the lymphocytes of 29 EPS-positive patients, 13 EPS-negative patients, and 30 healthy volunteers. The activities of A and B isoforms of hexosaminidase were higher in EPS-positive patients than EPS-negative patients and healthy controls. Multivariate analysis suggested an interaction with increased B isoform activity and EPS side effects in female bipolar disorder patients. Higher levels of hexosaminidase enzyme activity may explain the frequent occurrence of antipsychotic-induced extrapyramidal side effects in mood disorder patients.

Original language	English (US)
Pages (from-to)	1214-1220
Number of pages	7
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	32
Issue number	5
DOIs	https://doi.org/10.1016/j.pnpbp.2008.03.008
State	Published - Jul 1 2008

Bibliographical note

Funding Information:
This research was supported by the Lithium Association in Izmir, Turkey. We would like to thank Marc Schuckit, MD, distinguished professor of psychiatry from University of California San Diego for his invaluable contributions and also thank John Fowler, MD, Kent Hospital, İzmir, revising the manuscript.

Keywords

Antipsychotic drug
Dopamine
Extrapyramidal side effect
Ganglioside
Hexosaminidase

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10.1016/j.pnpbp.2008.03.008

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Tunca, Z., Resmi, H., Ozkara, H. A., Ciliv, G., Celtikci, B., Alptekin, K., Ozerdem, A., Akdede, B. K., Baykara, B., Birsoy, B., & Ergor, G. (2008). Increased hexosaminidase activity in antipsychotic-induced extrapyramidal side effects: Possible association with higher occurrence in bipolar disorder patients. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32(5), 1214-1220. https://doi.org/10.1016/j.pnpbp.2008.03.008

Increased hexosaminidase activity in antipsychotic-induced extrapyramidal side effects: Possible association with higher occurrence in bipolar disorder patients. / Tunca, Zeliha; Resmi, Halil; Ozkara, H. Asuman et al.
In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 32, No. 5, 01.07.2008, p. 1214-1220.

Research output: Contribution to journal › Article › peer-review

Tunca, Z, Resmi, H, Ozkara, HA, Ciliv, G, Celtikci, B, Alptekin, K, Ozerdem, A, Akdede, BK, Baykara, B, Birsoy, B & Ergor, G 2008, 'Increased hexosaminidase activity in antipsychotic-induced extrapyramidal side effects: Possible association with higher occurrence in bipolar disorder patients', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 32, no. 5, pp. 1214-1220. https://doi.org/10.1016/j.pnpbp.2008.03.008

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abstract = "Dystonic movements and Parkinsonism are frequently seen in gangliosidoses and these conditions have been reported to modify dopaminergic plasticity. We investigated whether the activity of hexosaminidase, a type-two ganglioside (GM2) degrading enzyme, correlates with drug-induced extrapyramidal system (EPS) side effects in psychiatric patients. We compared hexosaminidase activity in the lymphocytes of 29 EPS-positive patients, 13 EPS-negative patients, and 30 healthy volunteers. The activities of A and B isoforms of hexosaminidase were higher in EPS-positive patients than EPS-negative patients and healthy controls. Multivariate analysis suggested an interaction with increased B isoform activity and EPS side effects in female bipolar disorder patients. Higher levels of hexosaminidase enzyme activity may explain the frequent occurrence of antipsychotic-induced extrapyramidal side effects in mood disorder patients.",

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AU - Akdede, Berna Kivircik

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AU - Birsoy, Bilge

AU - Ergor, Gul

N1 - Funding Information: This research was supported by the Lithium Association in Izmir, Turkey. We would like to thank Marc Schuckit, MD, distinguished professor of psychiatry from University of California San Diego for his invaluable contributions and also thank John Fowler, MD, Kent Hospital, İzmir, revising the manuscript.

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N2 - Dystonic movements and Parkinsonism are frequently seen in gangliosidoses and these conditions have been reported to modify dopaminergic plasticity. We investigated whether the activity of hexosaminidase, a type-two ganglioside (GM2) degrading enzyme, correlates with drug-induced extrapyramidal system (EPS) side effects in psychiatric patients. We compared hexosaminidase activity in the lymphocytes of 29 EPS-positive patients, 13 EPS-negative patients, and 30 healthy volunteers. The activities of A and B isoforms of hexosaminidase were higher in EPS-positive patients than EPS-negative patients and healthy controls. Multivariate analysis suggested an interaction with increased B isoform activity and EPS side effects in female bipolar disorder patients. Higher levels of hexosaminidase enzyme activity may explain the frequent occurrence of antipsychotic-induced extrapyramidal side effects in mood disorder patients.

AB - Dystonic movements and Parkinsonism are frequently seen in gangliosidoses and these conditions have been reported to modify dopaminergic plasticity. We investigated whether the activity of hexosaminidase, a type-two ganglioside (GM2) degrading enzyme, correlates with drug-induced extrapyramidal system (EPS) side effects in psychiatric patients. We compared hexosaminidase activity in the lymphocytes of 29 EPS-positive patients, 13 EPS-negative patients, and 30 healthy volunteers. The activities of A and B isoforms of hexosaminidase were higher in EPS-positive patients than EPS-negative patients and healthy controls. Multivariate analysis suggested an interaction with increased B isoform activity and EPS side effects in female bipolar disorder patients. Higher levels of hexosaminidase enzyme activity may explain the frequent occurrence of antipsychotic-induced extrapyramidal side effects in mood disorder patients.

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Increased hexosaminidase activity in antipsychotic-induced extrapyramidal side effects: Possible association with higher occurrence in bipolar disorder patients

Abstract

Bibliographical note

Keywords

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