Increased hepatocyte growth factor levels over 2 years are associated with coronary heart disease: the Multi-Ethnic Study of Atherosclerosis (MESA)

Paul A. Decker, Nicholas B. Larson, Elizabeth J. Bell, James S. Pankow, Naomi Q. Hanson, Christina L. Wassel, Michael Y. Tsai, Suzette J. Bielinski

Research output: Contribution to journalLetterpeer-review

3 Scopus citations

Abstract

Hepatocyte growth factor (HGF) is associated with subclinical and clinical atherosclerosis. However, the significance of change in HGF and development of atherosclerotic disease is unknown. In a large and diverse population-based cohort, we report that change in the biomarker HGF is an independent predictor of incident CHD.

Original languageEnglish (US)
Pages (from-to)30-34
Number of pages5
JournalAmerican Heart Journal
Volume213
DOIs
StatePublished - Jul 2019

Bibliographical note

Funding Information:
This research was supported by the NIH contracts N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168 and N01-HC-95169 from the National Heart, Lung, and Blood Institute (NHLBI) at NIH and by grants UL1-TR-000040 and UL1-TR-001079 from National Center for Research Resources at NIH. Funding for adhesion protein levels was provided by the NHLBI by grant R01 HL98077. Dr. Bell was supported by the NIH T32 Training Grant HL07111-40.

Publisher Copyright:
© 2019 Elsevier Inc.

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