Increased efficiency of phorbol ester-induced lytic reactivation of Kaposi's sarcoma-associated herpesvirus during S phase

Shane C. McAllister, Scott G. Hansen, Ilhem Messaoudi, Janko Nikolich-Zugich, Ashlee V. Moses

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Expression of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic genes is thought to be essential for the establishment and progression of KSHV-induced diseases. The inefficiency of lytic reactivation in various in vitro systems hampers the study of lytic genes in the context of whole virus. We report here increased expression of KSHV lytic genes and increased release of progeny virus when synchronized cultures of body cavity-based lymphoma-1 cells are treated with a phorbol ester during S phase of the cell cycle.

Original languageEnglish (US)
Pages (from-to)2626-2630
Number of pages5
JournalJournal of virology
Volume79
Issue number4
DOIs
StatePublished - Feb 2005

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