Increased carotid intima-media thickness is not associated with T-cell activation nor with cytomegalovirus in HIV-infected neversmoker patients

Tiphaine Goulenok, Anders Boyd, Martin Larsen, Solène Fastenackels, Franck Boccara, Jean Luc Meynard, Nabila Hadour, Assia Samri, Moïse Desvarieux, Brigitte Autrana, Victor Appay, Pierre Marie Girard, Delphine Sauce, Jean Phillipe Bastard, Jacqueline Capeau, Beny Charbit, Ariel Cohen, Ryan T. Demmer, Soraya Fellahi, Ziad MallatAlain Tedgui, CHIC Study group

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Objectives: Increased risk of cardiovascular disease in patients infected with HIV has been attributed to immune activation, inflammation, and immunosenescence, all of which are linked to chronic immune activation by viral infections, particularly cytomegalovirus (CMV). Our aim is to evaluate the impact of these atherogenic markers in HIV-infected patients who never smoked. Design: Exposure-matched, cross-sectional study. Methods: In 59 HIV-infected individuals [n=30 undergoing >4 years of antiretroviral therapy (ART); n=29 never treated with ART] and 30 age-matched HIV-negative controls, we measured the level of activation and senescence, as well as the frequency of CMV-specific T cells, on peripheral blood mononuclear cells, while examining their association with carotid intima-media thickness. Partial correlations were adjusted for age, systolic blood pressure, and nadir CD4 cell count. Results: The previously described roles of T-cell activation, CMV, and immunosenescence in the atherosclerotic risk of HIV-infected patients, as assessed by carotid intima- media thickness, were not apparent in our cohort of particularly 'healthy' HIV-infected never-smokers. Conclusion: In HIV-infected individuals at low cardiovascular disease risk, our data show that the increased risk of carotid atherosclerosis is not associated with immunological markers described to be associated with HIV disease progression.

Original languageEnglish (US)
Pages (from-to)287-293
Number of pages7
JournalAIDS
Volume29
Issue number3
DOIs
StatePublished - 2015

Keywords

  • Atherosclerosis
  • Cytomegalovirus
  • HIV
  • Immune activation
  • Inflammation
  • T cells

Fingerprint Dive into the research topics of 'Increased carotid intima-media thickness is not associated with T-cell activation nor with cytomegalovirus in HIV-infected neversmoker patients'. Together they form a unique fingerprint.

Cite this