Increase of galanin-like immunoreactivity in rat hypothalamic arcuate neurons after peripheral nerve injury

Hiroki Imbe, Tetsuya Abe, Keiichiro Okamoto, Makoto Sato, Hiroki Ito, Shunji Kumabe, Emiko Senba

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Galanin and galanin receptors are widely distributed within the central nervous system, and may play important roles in pain signaling and modulation. In the present study, we examined the galanin immunoreactivity (IR) in the hypothalamus and the amygdala following peripheral nerve injury. Four weeks after the operation, the ipsilateral mechanical threshold in the spared nerve injury (SNI) group (0.87 ± 0.33 g) was significantly lower than that in the sham group (12.53 ± 3.41 g; P < 0.05). In the SNI group, the number of galanin-IR neurons per section in the arcuate nucleus (Arc) of the hypothalamus was 10.2 ± 1.7, significantly higher than that in the sham group (5.6 ± 1.0; P < 0.05). These data suggest that the galanin-ergic neurons in the Arc may be involved in the functional modulation of descending pain modulation system following peripheral nerve injury.

Original languageEnglish (US)
Pages (from-to)102-106
Number of pages5
JournalNeuroscience Letters
Volume368
Issue number1
DOIs
StatePublished - Sep 16 2004

Keywords

  • Galanin, Peripheral nerve injury, Hypothalamus, Neuropathic pain

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