Increase of creatine kinase activity in the visual cortex of human brain during visual stimulation: A 31P NMR magnetization transfer study

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Abstract

31P magnetic resonance spectroscopy was used to investigate changes in high energy phosphate levels and creatine kinase (CK) kinetics induced in the human visual cortex during photic stimulation. CK kinetics was evaluated by measuring the apparent unidirectional rate constant (k(f)) in the 'forward' direction (i.e., in the direction of ATP synthesis from phosphocreatine). k(f) increased 34% in the visual cortex areas during stimulation without significant changes of steady-state concentration of high energy phosphate compounds, indicating that CK turnover is elevated during increased neuronal activity.

Original languageEnglish (US)
Pages (from-to)551-557
Number of pages7
JournalMagnetic resonance in medicine
Volume38
Issue number4
DOIs
StatePublished - Oct 1 1997

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Keywords

  • Creatine kinase activity
  • Magnetization transfer
  • P NMR
  • Visual cortex
  • Visual stimulation

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