Abstract
Chimeric antigen receptor (CAR) T cell therapy represents the first U.S. Food and Drug Administration approved gene therapy and these engineered cells function with unprecedented efficacy in the treatment of refractory CD19 positive hematologic malignancies. CAR translation to solid tumors is also being actively investigated; however, efficacy to date has been variable due to tumor-evolved mechanisms that inhibit local immune cell activity. To bolster the potency of CAR-T cells, modulation of the immunosuppressive tumor microenvironment with immune-checkpoint blockade is a promising strategy. The impact of this approach on hematological malignancies is in its infancy, and in this review we discuss CAR-T cells and their synergy with immune-checkpoint blockade.
| Original language | English (US) |
|---|---|
| Article number | 340 |
| Journal | International journal of molecular sciences |
| Volume | 19 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2018 |
Bibliographical note
Publisher Copyright:© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Adoptive T cell therapy
- CRISPR/Cas9
- Cancer immunotherapy
- Chimeric antigen receptors
- Gene editing
- Gene therapy
- Immune-checkpoint
- PD-1
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