Incidence pattern and treatment of a clinical entity - Overswinging or circadian hyperamplitudetension (CHAT)

Y. Watanabe, G. Cornelissen, F. Halberg, C. Bingham, J. Siegelova, K. Otsuka, T. Kikuchi

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Systolic (S)and/or diastolic (D) circadian hyperamplitudetension (CHAT) is defined as a circadian blood pressure (BP) amplitude above the upper 95% prediction limit of clinically healthy peers, the amplitude being computed by the least-squares fit of a 24-hour cosine curve to the dam. On a population basis, CHAT is associated with an elevated risk of ischemic stroke and nephropathy. We show that CHAT occurs preferentially in patients with a MESOR (midline-estimating statistic of rhythm, a rhythm-adjusted mean) of BP intermediate between MESOR-normotension and MESOR-hypertension, as prior evidence suggests; and that CHAT can be corrected by pharmacologic or non- pharmacologic treatment. We recommend an initial 7-day ambulatory monitoring span (rather than a single 24-hour profile) for the individualized diagnosis of CHAT in practice.

Original languageEnglish (US)
Pages (from-to)245-26l
JournalScripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae
Volume70
Issue number6
StatePublished - Dec 1 1997

Keywords

  • 24-h Mood pressure
  • Overswinging
  • Therapy

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