Abstract
Animal models are frequently used as surrogates to understand human disease. In the fungal pathogen Cryptococcus species complex, several variations of a mouse model of disease were developed that recapitulate different aspects of human disease. These mouse models have been implemented using various inbred and outbred mouse backgrounds, many of which have genetic differences that can influence host response and disease outcome. In this review, we will discuss the most commonly used inbred mouse backgrounds in C. neoformans infection models.
| Original language | English (US) |
|---|---|
| Article number | 426 |
| Journal | Journal of Fungi |
| Volume | 10 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 2024 |
Bibliographical note
Publisher Copyright:© 2024 by the authors.
Keywords
- Cryptococcus neoformans
- cryptococcal immune reconstitution inflammatory syndrome
- cryptococcal meningitis
- damage-response framework
- fungus
- host immune responses
- host–pathogen interactions
- human fungal pathogen
- inbred mouse models
- latent C. neoformans infection
PubMed: MeSH publication types
- Journal Article
- Review