A total of 817 human immunodeficiency virus-infected Ethiopians with CD4 <150 cells/mL underwent plasma cryptococcal antigen (CRAG) screening. CRAG prevalence was 6.2%. Of participants with plasma CRAG titers >1:640, 96% (27 of 28) had cryptococcal meningitis (cerebrospinal fluid CRAGpositive) whereas 50% (7 of 14) with 1:160-1:320 titers had meningitis. With fluconazole 1200 mg/d therapy, 68% of meningitis patients (23 of 34) died within 3 months. Plasma CRAG titers >1:160 predict meningitis, requiring more intensive antifungal therapy.
Bibliographical noteFunding Information:
Financial support. This work is supported by the National Center for Advancing Translational Sciences, National Institutes of Health (grant UL1TR000114 to R. R. and R01AI118511 to D. R. B., R. R.).
© 2017 The Author. Published by Oxford University Press for the Infectious Diseases Society of America.
- Cryptococcal meningitis /PC
- Cryptococcosis /PC
- Mass Screening
- Prevention & Control